Cell atlas - STAC3 - The Human Protein Atlas

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STAC3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	STAC3
Gene description	SH3 and cysteine rich domain 3
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enriched (RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA039285 , HPA039527
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (validated)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039285	RH-30	Nucleoplasm
	HPA039285	RH-30	Cytosol
	HPA039285	U-2 OS	No staining
	HPA039285	U-251 MG	No staining
	HPA039527	RH-30	Nucleoplasm
	HPA039527	RH-30	Cytosol

GENE INFORMATION
Gene name	STAC3 (HGNC Symbol)
Synonyms	MGC2793
Description	SH3 and cysteine rich domain 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy. [provided by RefSeq, Nov 2013]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	57243453 - 57251193
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185482 (version 83.38)
Entrez gene	246329
UniProt	Q96MF2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MF2
Antibodypedia	STAC3 antibodies

PROTEIN BROWSER

STAC3-001	STAC3-003	STAC3-004	STAC3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STAC3-001 ENSP00000329200 ENST00000332782	Q96MF2 [Direct mapping] SH3 and cysteine-rich domain-containing protein 3 A0A024RB38 [Target identity:100%; Query identity:100%] SH3 and cysteine rich domain 3, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007274 [neuromuscular synaptic transmission] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] GO:0048741 [skeletal muscle fiber development] Show all	364 aa 41.5 kDa	No	0
STAC3-003 ENSP00000452068 ENST00000554578	Q96MF2 [Direct mapping] SH3 and cysteine-rich domain-containing protein 3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007274 [neuromuscular synaptic transmission] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] Show all	325 aa 37.1 kDa	No	0
STAC3-004 ENSP00000441515 ENST00000546246	Q96MF2 [Direct mapping] SH3 and cysteine-rich domain-containing protein 3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007274 [neuromuscular synaptic transmission] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] Show all	178 aa 20.3 kDa	No	0
STAC3-005 ENSP00000452299 ENST00000553489	G3V5D4 [Direct mapping] SH3 and cysteine-rich domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] Show all	168 aa 19.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.