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IRF7

GENERAL INFORMATION

Gene name

 IRF7

Gene description

 Interferon regulatory factor 7

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (EFO-21, Karpas-707, SCLC-21H, SK-BR-3)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues, distinct expression in lymphatic organs.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA052757 , CAB017694
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052757
CAB017694

GENE INFORMATION

Gene name

 IRF7

Synonyms

Description

 Interferon regulatory factor 7 (HGNC Symbol)

Entrez gene summary

 IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 612553 - 615999

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185507 (version 83.38)

Entrez gene

 3665

UniProt

 Q92985 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92985

Antibodypedia

 IRF7 antibodies

PROTEIN BROWSER
IRF7-001
IRF7-002
IRF7-005
IRF7-006
IRF7-201
IRF7-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRF7-001
ENSP00000329411
ENST00000330243
Q92985 [Direct mapping]
Interferon regulatory factor 7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0002819 [regulation of adaptive immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009615 [response to virus]
GO:0010008 [endosome membrane]
GO:0019043 [establishment of viral latency]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032607 [interferon-alpha production]
GO:0032608 [interferon-beta production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034124 [regulation of MyD88-dependent toll-like receptor signaling pathway]
GO:0034127 [regulation of MyD88-independent toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0045087 [innate immune response]
GO:0045655 [regulation of monocyte differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050776 [regulation of immune response]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:2000110 [negative regulation of macrophage apoptotic process]
Show all
 516 aa
55.6 kDa 		No 0
IRF7-002
ENSP00000380704
ENST00000397574
Q92985 [Direct mapping]
Interferon regulatory factor 7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0002819 [regulation of adaptive immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009615 [response to virus]
GO:0010008 [endosome membrane]
GO:0019043 [establishment of viral latency]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032607 [interferon-alpha production]
GO:0032608 [interferon-beta production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034124 [regulation of MyD88-dependent toll-like receptor signaling pathway]
GO:0034127 [regulation of MyD88-independent toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0045087 [innate immune response]
GO:0045655 [regulation of monocyte differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050776 [regulation of immune response]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:2000110 [negative regulation of macrophage apoptotic process]
Show all
 503 aa
54.3 kDa 		No 0
IRF7-005
ENSP00000331803
ENST00000348655
Q92985 [Direct mapping]
Interferon regulatory factor 7
A0A024RCA2 [Target identity:100%; Query identity:100%]
Interferon regulatory factor 7, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0002819 [regulation of adaptive immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009615 [response to virus]
GO:0010008 [endosome membrane]
GO:0019043 [establishment of viral latency]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032607 [interferon-alpha production]
GO:0032608 [interferon-beta production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034124 [regulation of MyD88-dependent toll-like receptor signaling pathway]
GO:0034127 [regulation of MyD88-independent toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0045087 [innate immune response]
GO:0045655 [regulation of monocyte differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050776 [regulation of immune response]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:2000110 [negative regulation of macrophage apoptotic process]
Show all
 474 aa
51.5 kDa 		No 0
IRF7-006
ENSP00000434009
ENST00000525445
E9PSE3 [Direct mapping]
Interferon regulatory factor 7
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 397 aa
42.3 kDa 		No 0
IRF7-201
ENSP00000380697
ENST00000397566
Q92985 [Direct mapping]
Interferon regulatory factor 7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0002819 [regulation of adaptive immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009615 [response to virus]
GO:0010008 [endosome membrane]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019043 [establishment of viral latency]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032607 [interferon-alpha production]
GO:0032608 [interferon-beta production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034124 [regulation of MyD88-dependent toll-like receptor signaling pathway]
GO:0034127 [regulation of MyD88-independent toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0045087 [innate immune response]
GO:0045351 [type I interferon biosynthetic process]
GO:0045655 [regulation of monocyte differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050776 [regulation of immune response]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:2000110 [negative regulation of macrophage apoptotic process]
Show all
 516 aa
55.6 kDa 		No 0
IRF7-202
ENSP00000380700
ENST00000397570
M9RSF4 [Direct mapping]
Interferon regulatory factor 7; Interferon regulatory factor 7 transcript variant e
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Predicted intracellular proteins
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 487 aa
52.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.