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BRCC3

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GENERAL INFORMATION

Gene name

 BRCC3

Gene description

 BRCA1/BRCA2-containing complex, subunit 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Mouse

 Localized to the Nuclear speckles in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA048737
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA048737 A-431 Nucleoplasm
HPA048737 U-2 OS Nucleoplasm
HPA048737 U-251 MG Nucleoplasm

MOUSE CELLS

Main location

 Nuclear speckles

Additional location

 Cytosol

Mouse gene

 ENSMUSG00000031201 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA048737 NIH 3T3 Nuclear speckles
Cytosol

GENE INFORMATION

Gene name

 BRCC3 (HGNC Symbol)

Synonyms

 BRCC36, C6.1A, CXorf53

Description

 BRCA1/BRCA2-containing complex, subunit 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 155071420 - 155123074

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185515 (version 83.38)

Entrez gene

 79184

UniProt

 P46736 (UniProt - Evidence at protein level)

neXtProt

 NX_P46736

Antibodypedia

 BRCC3 antibodies

PROTEIN BROWSER
BRCC3-001
BRCC3-002
BRCC3-003
BRCC3-004
BRCC3-006
BRCC3-007
BRCC3-201
BRCC3-202
BRCC3-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRCC3-001
ENSP00000358474
ENST00000369462
P46736 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0008237 [metallopeptidase activity]
GO:0010165 [response to X-ray]
GO:0010212 [response to ionizing radiation]
GO:0030234 [enzyme regulator activity]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0046872 [metal ion binding]
GO:0050790 [regulation of catalytic activity]
GO:0070531 [BRCA1-A complex]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070537 [histone H2A K63-linked deubiquitination]
GO:0070552 [BRISC complex]
Show all
 316 aa
36.1 kDa 		No 0
BRCC3-002
ENSP00000328641
ENST00000330045
P46736 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0008237 [metallopeptidase activity]
GO:0010165 [response to X-ray]
GO:0010212 [response to ionizing radiation]
GO:0030234 [enzyme regulator activity]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0046872 [metal ion binding]
GO:0050790 [regulation of catalytic activity]
GO:0070531 [BRCA1-A complex]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070537 [histone H2A K63-linked deubiquitination]
GO:0070552 [BRISC complex]
Show all
 291 aa
33.1 kDa 		No 0
BRCC3-003
ENSP00000381988
ENST00000399026
A0A0A0MS96 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 90 aa
10.4 kDa 		No 0
BRCC3-004
ENSP00000358471
ENST00000369459
P46736 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0008237 [metallopeptidase activity]
GO:0010165 [response to X-ray]
GO:0010212 [response to ionizing radiation]
GO:0030234 [enzyme regulator activity]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0046872 [metal ion binding]
GO:0050790 [regulation of catalytic activity]
GO:0070531 [BRCA1-A complex]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070537 [histone H2A K63-linked deubiquitination]
GO:0070552 [BRISC complex]
Show all
 247 aa
28 kDa 		No 0
BRCC3-006
ENSP00000344103
ENST00000340647
P46736 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0008237 [metallopeptidase activity]
GO:0010165 [response to X-ray]
GO:0010212 [response to ionizing radiation]
GO:0030234 [enzyme regulator activity]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0046872 [metal ion binding]
GO:0050790 [regulation of catalytic activity]
GO:0070531 [BRCA1-A complex]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070537 [histone H2A K63-linked deubiquitination]
GO:0070552 [BRISC complex]
Show all
 292 aa
33.2 kDa 		No 0
BRCC3-007
ENSP00000413170
ENST00000411985
X6RJS7 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 226 aa
25.8 kDa 		No 0
BRCC3-201
ENSP00000381998
ENST00000399042
H9KVA9 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
Show all
 317 aa
36.2 kDa 		No 0
BRCC3-202
ENSP00000482836
ENST00000620502
A0A087WZR3 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 293 aa
33.4 kDa 		No 0
BRCC3-203
ENSP00000486287
ENST00000630295
A0A0D9SF50 [Direct mapping]
Lys-63-specific deubiquitinase BRCC36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 317 aa
36.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.