Expression of DLK1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DLK1
Gene description	Delta-like 1 homolog (Drosophila)
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer)
HPA (cell line):	Group enriched (AF22, Hep G2, SH-SY5Y)
HPA (normal tissue):	Group enriched (adrenal gland, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in adrenal gland, islets of Langerhans and in endothelial and stromal cells in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA053879 , HPA062262 , CAB005872
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA053879	HPA062262	CAB005872

GENE INFORMATION
Gene name	DLK1 (HGNC Symbol)
Synonyms	Delta1, FA1, pG2, Pref-1, ZOG
Description	Delta-like 1 homolog (Drosophila) (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	100725705 - 100738224
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185559 (version 83.38)
Entrez gene	8788
UniProt	P80370 (UniProt - Evidence at protein level)
neXtProt	NX_P80370
Antibodypedia	DLK1 antibodies

PROTEIN BROWSER

DLK1-001	DLK1-003	DLK1-007	DLK1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLK1-001 ENSP00000340292 ENST00000341267	P80370 [Direct mapping] Protein delta homolog 1 Fetal antigen 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007219 [Notch signaling pathway] GO:0009791 [post-embryonic development] GO:0009897 [external side of plasma membrane] GO:0010468 [regulation of gene expression] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0045746 [negative regulation of Notch signaling pathway] GO:0048706 [embryonic skeletal system development] Show all	383 aa 41.3 kDa	Yes	1
DLK1-003 ENSP00000331081 ENST00000331224	P80370 [Direct mapping] Protein delta homolog 1 Fetal antigen 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007219 [Notch signaling pathway] GO:0016021 [integral component of membrane] GO:0045746 [negative regulation of Notch signaling pathway] Show all	310 aa 33.1 kDa	Yes	1
DLK1-007 ENSP00000376589 ENST00000392848	G3XAH5 [Direct mapping] Protein delta homolog 1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	97 aa 10.3 kDa	Yes	0
DLK1-009 ENSP00000450821 ENST00000556051	G3V2R7 [Direct mapping] Protein delta homolog 1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	136 aa 14.5 kDa	Yes	0