Expression of LSAMP in cancer - Summary - The Human Protein Atlas

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LSAMP

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	LSAMP
Gene description	Limbic system-associated membrane protein
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Group enriched (AF22, SH-SY5Y, WM-115)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	LSAMP (HGNC Symbol)
Synonyms	IGLON3, LAMP
Description	Limbic system-associated membrane protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a neuronal surface glycoprotein found in cortical and subcortical regions of the limbic system. During development of the limbic system, this encoded protein is found on the surface of axonal membranes and growth cones, where it acts as a selective homophilic adhesion molecule, and guides the development of specific patterns of neuronal connections. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q13.31
Chromosome location (bp)	115802363 - 117139389
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185565 (version 83.38)
Entrez gene	4045
UniProt	Q13449 (UniProt - Evidence at protein level)
neXtProt	NX_Q13449
Antibodypedia	LSAMP antibodies

PROTEIN BROWSER

LSAMP-001	LSAMP-002	LSAMP-006	LSAMP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSAMP-001 ENSP00000419000 ENST00000490035	Q13449 [Direct mapping] Limbic system-associated membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0007399 [nervous system development] GO:0009986 [cell surface] GO:0016337 [single organismal cell-cell adhesion] GO:0031225 [anchored component of membrane] GO:0035641 [locomotory exploration behavior] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0050767 [regulation of neurogenesis] Show all	338 aa 37.4 kDa	Yes	1
LSAMP-002 ENSP00000328455 ENST00000333617	H3BLU2 [Direct mapping] Limbic system-associated membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0050767 [regulation of neurogenesis] Show all	345 aa 38 kDa	Yes	1
LSAMP-006 ENSP00000418506 ENST00000474851	C9J5G3 [Direct mapping] Limbic system-associated membrane protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0009986 [cell surface] GO:0016337 [single organismal cell-cell adhesion] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0050767 [regulation of neurogenesis] Show all	205 aa 23 kDa	No	0
LSAMP-201 ENSP00000443429 ENST00000539563	F5H5G1 [Direct mapping] Limbic system-associated membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0050767 [regulation of neurogenesis] Show all	288 aa 31.7 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.