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PDIA2

GENERAL INFORMATION

Gene name

 PDIA2

Gene description

 Protein disulfide isomerase family A, member 2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (pancreatic cancer)
HPA (cell line):Cell line enhanced (HEK93, Hep G2, MCF7, SH-SY5Y)
HPA (normal tissue):Tissue enriched (pancreas)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in exocrine glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA051692 , HPA053492
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051692
HPA053492

GENE INFORMATION

Gene name

 PDIA2 (HGNC Symbol)

Synonyms

 PDA2, PDI, PDIP, PDIR

Description

 Protein disulfide isomerase family A, member 2 (HGNC Symbol)

Entrez gene summary

 Protein disulfide isomerases (EC 5.3.4.1), such as PDIP, are endoplasmic reticulum (ER) resident proteins that catalyze protein folding and thiol-disulfide interchange reactions (Desilva et al., 1996 [PubMed 8561901]).[supplied by OMIM, Mar 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 283152 - 287215

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185615 (version 83.38)

Entrez gene

 64714

UniProt

 Q13087 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13087

Antibodypedia

 PDIA2 antibodies

PROTEIN BROWSER
PDIA2-001
PDIA2-005
PDIA2-007
PDIA2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDIA2-001
ENSP00000219406
ENST00000219406
Q13087 [Direct mapping]
Protein disulfide-isomerase A2
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Enzymes
   ENZYME proteins
   Isomerase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0006621 [protein retention in ER lumen]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016853 [isomerase activity]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031545 [peptidyl-proline 4-dioxygenase activity]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
GO:1902175 [regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
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 525 aa
58.2 kDa 		Yes 0
PDIA2-005
ENSP00000392277
ENST00000456379
H0Y4J5 [Direct mapping]
Protein disulfide-isomerase A2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005623 [cell]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031545 [peptidyl-proline 4-dioxygenase activity]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045454 [cell redox homeostasis]
GO:1902175 [regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
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 227 aa
25 kDa 		Yes 0
PDIA2-007
ENSP00000405081
ENST00000435833
Q4TT65 [Direct mapping]
Protein disulfide isomerase family A, member 2; Protein disulfide-isomerase A2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005623 [cell]
GO:0016853 [isomerase activity]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031545 [peptidyl-proline 4-dioxygenase activity]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045454 [cell redox homeostasis]
GO:1902175 [regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
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 154 aa
17.2 kDa 		No 0
PDIA2-008
ENSP00000384410
ENST00000404312
Q13087 [Direct mapping]
Protein disulfide-isomerase A2
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Enzymes
   ENZYME proteins
   Isomerase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0006621 [protein retention in ER lumen]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016853 [isomerase activity]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031545 [peptidyl-proline 4-dioxygenase activity]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
GO:1902175 [regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
 522 aa
57.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.