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LMLN

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GENERAL INFORMATION

Gene name

 LMLN

Gene description

 Leishmanolysin-like (metallopeptidase M8 family)

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the focal adhesion sites.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Focal adhesion sites (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA016481 , HPA028844
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the focal adhesion sites.

Main location

 Cytosol (supported)

Additional location

 Focal adhesion sites (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA016481 A-431 Cytosol
HPA016481 U-2 OS Cytosol
HPA016481 U-251 MG Cytosol
HPA028844 A-431 Focal adhesion sites
Cytosol
HPA028844 U-2 OS Cytosol
HPA028844 U-251 MG Cytosol

GENE INFORMATION

Gene name

 LMLN (HGNC Symbol)

Synonyms

 Gp63, Msp

Description

 Leishmanolysin-like (metallopeptidase M8 family) (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 197960200 - 198043720

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185621 (version 83.38)

Entrez gene

 89782

UniProt

 Q96KR4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96KR4

Antibodypedia

 LMLN antibodies

PROTEIN BROWSER
LMLN-001
LMLN-002
LMLN-004
LMLN-005
LMLN-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LMLN-001
ENSP00000328829
ENST00000330198
Q96KR4 [Direct mapping]
Leishmanolysin-like peptidase
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0007067 [mitotic nuclear division]
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 655 aa
73.6 kDa 		No 1
LMLN-002
ENSP00000418324
ENST00000482695
Q96KR4 [Direct mapping]
Leishmanolysin-like peptidase
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0007067 [mitotic nuclear division]
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 640 aa
72.8 kDa 		No 1
LMLN-004
ENSP00000410926
ENST00000420910
Q96KR4 [Direct mapping]
Leishmanolysin-like peptidase
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0007067 [mitotic nuclear division]
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 692 aa
78.1 kDa 		No 1
LMLN-005
ENSP00000328611
ENST00000332636
F8WCE5 [Direct mapping]
Leishmanolysin-like peptidase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 603 aa
68.2 kDa 		No 1
LMLN-006
ENSP00000390872
ENST00000419117
C9JF40 [Direct mapping]
Leishmanolysin-like peptidase
Show all
Predicted intracellular proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
Show all
 151 aa
17.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.