Expression of P4HB in cancer - Summary - The Human Protein Atlas

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P4HB

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	P4HB
Gene description	Prolyl 4-hydroxylase, beta polypeptide
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA018884 , CAB012463
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018884	CAB012463

GENE INFORMATION
Gene name	P4HB (HGNC Symbol)
Synonyms	DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PO4DB, PO4HB, PROHB
Description	Prolyl 4-hydroxylase, beta polypeptide (HGNC Symbol)
Entrez gene summary	This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81843159 - 81860694
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185624 (version 83.38)
Entrez gene	5034
UniProt	P07237 (UniProt - Evidence at protein level)
neXtProt	NX_P07237
Antibodypedia	P4HB antibodies

PROTEIN BROWSER

P4HB-001	P4HB-002	P4HB-019	P4HB-021	P4HB-022	P4HB-023	P4HB-024	P4HB-025	P4HB-026	P4HB-027	P4HB-029

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P4HB-001 ENSP00000327801 ENST00000331483	P07237 [Direct mapping] Protein disulfide-isomerase A0A024R8S5 [Target identity:100%; Query identity:100%] Protein disulfide-isomerase Show all	Enzymes ENZYME proteins Isomerase Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0003756 [protein disulfide isomerase activity] GO:0004175 [endopeptidase activity] GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005925 [focal adhesion] GO:0006457 [protein folding] GO:0006508 [proteolysis] GO:0009897 [external side of plasma membrane] GO:0016222 [procollagen-proline 4-dioxygenase complex] GO:0016853 [isomerase activity] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0019899 [enzyme binding] GO:0030198 [extracellular matrix organization] GO:0034663 [endoplasmic reticulum chaperone complex] GO:0034976 [response to endoplasmic reticulum stress] GO:0042157 [lipoprotein metabolic process] GO:0042470 [melanosome] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045454 [cell redox homeostasis] GO:0046598 [positive regulation of viral entry into host cell] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] GO:0071456 [cellular response to hypoxia] GO:1902175 [regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] Show all	508 aa 57.1 kDa	Yes	0
P4HB-002 ENSP00000388117 ENST00000415593	H0Y3Z3 [Direct mapping] Protein disulfide-isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006457 [protein folding] GO:0008152 [metabolic process] GO:0016853 [isomerase activity] GO:0045454 [cell redox homeostasis] Show all	274 aa 31.4 kDa	No	0
P4HB-019 ENSP00000460612 ENST00000574914	I3L3P5 [Direct mapping] Protein disulfide-isomerase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006457 [protein folding] GO:0045454 [cell redox homeostasis] Show all	156 aa 16.9 kDa	Yes	0
P4HB-021 ENSP00000388374 ENST00000439918	H7BZ94 [Direct mapping] Protein disulfide-isomerase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0008152 [metabolic process] GO:0016853 [isomerase activity] GO:0045454 [cell redox homeostasis] Show all	464 aa 52.5 kDa	Yes	0
P4HB-022 ENSP00000460088 ENST00000573778	I3L312 [Direct mapping] Protein disulfide-isomerase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006457 [protein folding] Show all	208 aa 23 kDa	Yes	0
P4HB-023 ENSP00000461718 ENST00000576390	I3L514 [Direct mapping] Protein disulfide-isomerase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006457 [protein folding] GO:0045454 [cell redox homeostasis] Show all	106 aa 11.6 kDa	Yes	0
P4HB-024 ENSP00000461791 ENST00000576052	I3NI03 [Direct mapping] Protein disulfide-isomerase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006457 [protein folding] GO:0008152 [metabolic process] GO:0016853 [isomerase activity] GO:0045454 [cell redox homeostasis] Show all	166 aa 18.5 kDa	Yes	0
P4HB-025 ENSP00000458300 ENST00000571617	I3L0S0 [Direct mapping] Protein disulfide-isomerase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006457 [protein folding] GO:0008152 [metabolic process] GO:0016853 [isomerase activity] GO:0045454 [cell redox homeostasis] Show all	148 aa 16.2 kDa	Yes	0
P4HB-026 ENSP00000460285 ENST00000576380	I3L398 [Direct mapping] Protein disulfide-isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] Show all	200 aa 23 kDa	No	0
P4HB-027 ENSP00000460741 ENST00000576541	I3L3U6 [Direct mapping] Protein disulfide-isomerase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006457 [protein folding] GO:0008152 [metabolic process] GO:0016853 [isomerase activity] GO:0045454 [cell redox homeostasis] Show all	188 aa 20.7 kDa	Yes	0
P4HB-029 ENSP00000461362 ENST00000570907	I3L4M2 [Direct mapping] Protein disulfide-isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006457 [protein folding] Show all	117 aa 13.5 kDa	No	0

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