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PBX1

GENERAL INFORMATION

Gene name

 PBX1

Gene description

 Pre-B-cell leukemia homeobox 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SK-BR-3)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues at variable levels, high expression in tissue stroma.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA003505 , HPA003881 , CAB018768
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA003505
HPA003881
CAB018768

GENE INFORMATION

Gene name

 PBX1

Synonyms

Description

 Pre-B-cell leukemia homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 164555584 - 164899296

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185630 (version 83.38)

Entrez gene

 5087

UniProt

 P40424 (UniProt - Evidence at protein level)

neXtProt

 NX_P40424

Antibodypedia

 PBX1 antibodies

PROTEIN BROWSER
«
PBX1-001
PBX1-002
PBX1-006
PBX1-007
PBX1-009
PBX1-012
PBX1-013
PBX1-017
PBX1-018
PBX1-019
PBX1-020
PBX1-201
PBX1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PBX1-001
ENSP00000405890
ENST00000420696
P40424 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
A0A024R919 [Target identity:100%; Query identity:100%]
Pre-B-cell leukemia transcription factor 1, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001655 [urogenital system development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006694 [steroid biosynthetic process]
GO:0007548 [sex differentiation]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0009954 [proximal/distal pattern formation]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0030278 [regulation of ossification]
GO:0030325 [adrenal gland development]
GO:0030326 [embryonic limb morphogenesis]
GO:0035019 [somatic stem cell population maintenance]
GO:0035162 [embryonic hemopoiesis]
GO:0042127 [regulation of cell proliferation]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0048568 [embryonic organ development]
GO:0048706 [embryonic skeletal system development]
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 430 aa
46.6 kDa 		No 0
PBX1-002
ENSP00000356872
ENST00000367897
P40424 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Q53YC7 [Target identity:100%; Query identity:100%]
Pre-B-cell leukemia transcription factor 1; Pre-B-cell leukemia transcription factor 1, isoform CRA_c
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006694 [steroid biosynthetic process]
GO:0007548 [sex differentiation]
GO:0008134 [transcription factor binding]
GO:0035019 [somatic stem cell population maintenance]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
Show all
 347 aa
38.4 kDa 		No 0
PBX1-006
ENSP00000473998
ENST00000485769
S4R377 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
Show all
 70 aa
7.4 kDa 		No 0
PBX1-007
ENSP00000341455
ENST00000340699
F8WA05 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 170 aa
18.2 kDa 		No 0
PBX1-009
ENSP00000453163
ENST00000482110
H0YLD4 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 129 aa
14.3 kDa 		No 0
PBX1-012
ENSP00000453188
ENST00000559240
H0YLF5 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 339 aa
37 kDa 		No 0
PBX1-013
ENSP00000452804
ENST00000559578
H0YKH1 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 159 aa
17.6 kDa 		No 0
PBX1-017
ENSP00000452727
ENST00000560641
H0YLB0 [Direct mapping]
Pre-B-cell leukemia transcription factor 1; Pre-B-cell leukemia transcription factor 1, isoform CRA_a
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 325 aa
35.2 kDa 		No 0
PBX1-018
ENSP00000453262
ENST00000559560
H0YLM3 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 97 aa
10.5 kDa 		No 0
PBX1-019
ENSP00000453331
ENST00000558837
H0YLT4 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 139 aa
15.6 kDa 		No 0
PBX1-020
ENSP00000485692
ENST00000627490
P40424 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006694 [steroid biosynthetic process]
GO:0007548 [sex differentiation]
GO:0008134 [transcription factor binding]
GO:0035019 [somatic stem cell population maintenance]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
Show all
 420 aa
46.3 kDa 		No 0
PBX1-201
ENSP00000439943
ENST00000540236
A0A0A0MTI0 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 342 aa
37.1 kDa 		No 0
PBX1-202
ENSP00000483563
ENST00000612123
A0A087X0P4 [Direct mapping]
Pre-B-cell leukemia transcription factor 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 259 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.