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ZFP36L1

GENERAL INFORMATION

Gene name

 ZFP36L1

Gene description

 ZFP36 ring finger protein-like 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA001301
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZFP36L1 (HGNC Symbol)

Synonyms

 Berg36, BRF1, cMG1, ERF1, RNF162B, TIS11B

Description

 ZFP36 ring finger protein-like 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 14

Cytoband

 q24.1

Chromosome location (bp)

 68787660 - 68796253

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185650 (version 83.38)

Entrez gene

 677

UniProt

 Q07352 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07352

Antibodypedia

 ZFP36L1 antibodies

PROTEIN BROWSER
ZFP36L1-001
ZFP36L1-002
ZFP36L1-003
ZFP36L1-004
ZFP36L1-005
ZFP36L1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZFP36L1-001
ENSP00000388402
ENST00000439696
Q07352 [Direct mapping]
Zinc finger protein 36, C3H1 type-like 1
A0A024R658 [Target identity:100%; Query identity:100%]
Zinc finger protein 36, C3H type-like 1, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0001570 [vasculogenesis]
GO:0003342 [proepicardium development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006402 [mRNA catabolic process]
GO:0006417 [regulation of translation]
GO:0006915 [apoptotic process]
GO:0007507 [heart development]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0017091 [AU-rich element binding]
GO:0021915 [neural tube development]
GO:0033077 [T cell differentiation in thymus]
GO:0035264 [multicellular organism growth]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0048568 [embryonic organ development]
GO:0060710 [chorio-allantoic fusion]
GO:0060712 [spongiotrophoblast layer development]
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 338 aa
36.3 kDa 		No 0
ZFP36L1-002
ENSP00000337386
ENST00000336440
Q07352 [Direct mapping]
Zinc finger protein 36, C3H1 type-like 1
A0A024R658 [Target identity:100%; Query identity:100%]
Zinc finger protein 36, C3H type-like 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010467 [gene expression]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 338 aa
36.3 kDa 		No 0
ZFP36L1-003
ENSP00000451093
ENST00000555997
G3V382 [Direct mapping]
Zinc finger protein 36, C3H1 type-like 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 69 aa
7.5 kDa 		No 0
ZFP36L1-004
ENSP00000450784
ENST00000557086
G3V2P5 [Direct mapping]
Zinc finger protein 36, C3H1 type-like 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
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 207 aa
22.8 kDa 		No 0
ZFP36L1-005
ENSP00000452119
ENST00000553375
G3V515 [Direct mapping]
Zinc finger protein 36, C3H1 type-like 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 189 aa
20.4 kDa 		No 0
ZFP36L1-006
ENSP00000450600
ENST00000557022
G3V2D5 [Direct mapping]
Zinc finger protein 36, C3H1 type-like 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 176 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.