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UBE2L3

GENERAL INFORMATION

Gene name

 UBE2L3

Gene description

 Ubiquitin-conjugating enzyme E2L 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA045609 , HPA062415
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable) and liver cancer (unfavourable).
Ovarian cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA045609
HPA062415

GENE INFORMATION

Gene name

 UBE2L3 (HGNC Symbol)

Synonyms

 UBCH7

Description

 Ubiquitin-conjugating enzyme E2L 3 (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 21549447 - 21624034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185651 (version 83.38)

Entrez gene

 7332

UniProt

 P68036 (UniProt - Evidence at protein level)

neXtProt

 NX_P68036

Antibodypedia

 UBE2L3 antibodies

PROTEIN BROWSER
UBE2L3-001
UBE2L3-201
UBE2L3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2L3-001
ENSP00000344259
ENST00000342192
P68036 [Direct mapping]
Ubiquitin-conjugating enzyme E2 L3
A0A024R1A4 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2L 3, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008283 [cell proliferation]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044770 [cell cycle phase transition]
GO:0044822 [poly(A) RNA binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0097027 [ubiquitin-protein transferase activator activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 154 aa
17.9 kDa 		No 0
UBE2L3-201
ENSP00000400906
ENST00000458578
P68036 [Direct mapping]
Ubiquitin-conjugating enzyme E2 L3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008283 [cell proliferation]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044770 [cell cycle phase transition]
GO:0044822 [poly(A) RNA binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0097027 [ubiquitin-protein transferase activator activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 212 aa
24 kDa 		No 0
UBE2L3-202
ENSP00000445931
ENST00000545681
P68036 [Direct mapping]
Ubiquitin-conjugating enzyme E2 L3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008283 [cell proliferation]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044770 [cell cycle phase transition]
GO:0044822 [poly(A) RNA binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0097027 [ubiquitin-protein transferase activator activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 122 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.