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PRAME

GENERAL INFORMATION

Gene name

 PRAME

Gene description

 Preferentially expressed antigen in melanoma

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (endometrial cancer, melanoma, ovarian cancer, testis cancer)
HPA (cell line):Cell line enhanced (K-562, SH-SY5Y)
HPA (normal tissue):Group enriched (epididymis, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in seminiferous ducts in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA045153
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (endometrial cancer, melanoma, ovarian cancer, testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA045153

GENE INFORMATION

Gene name

 PRAME (HGNC Symbol)

Synonyms

 CT130, MAPE

Description

 Preferentially expressed antigen in melanoma (HGNC Symbol)

Entrez gene summary

 This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Chromosome

 22

Cytoband

 q11.22

Chromosome location (bp)

 22547701 - 22559361

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185686 (version 83.38)

Entrez gene

 23532

UniProt

 P78395 (UniProt - Evidence at protein level)

neXtProt

 NX_P78395

Antibodypedia

 PRAME antibodies

PROTEIN BROWSER
PRAME-001
PRAME-003
PRAME-004
PRAME-005
PRAME-006
PRAME-008
PRAME-009
PRAME-012
PRAME-201
PRAME-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRAME-001
ENSP00000381728
ENST00000398743
P78395 [Direct mapping]
Melanoma antigen preferentially expressed in tumors
A0A024R1E6 [Target identity:100%; Query identity:100%]
Preferentially expressed antigen in melanoma, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0030154 [cell differentiation]
GO:0040008 [regulation of growth]
GO:0042974 [retinoic acid receptor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0045596 [negative regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048387 [negative regulation of retinoic acid receptor signaling pathway]
Show all
 509 aa
57.9 kDa 		No 0
PRAME-003
ENSP00000385198
ENST00000402697
P78395 [Direct mapping]
Melanoma antigen preferentially expressed in tumors
A0A024R1E6 [Target identity:100%; Query identity:100%]
Preferentially expressed antigen in melanoma, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0030154 [cell differentiation]
GO:0040008 [regulation of growth]
GO:0042974 [retinoic acid receptor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0045596 [negative regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048387 [negative regulation of retinoic acid receptor signaling pathway]
Show all
 509 aa
57.9 kDa 		No 0
PRAME-004
ENSP00000384343
ENST00000405655
P78395 [Direct mapping]
Melanoma antigen preferentially expressed in tumors
A0A024R1E6 [Target identity:100%; Query identity:100%]
Preferentially expressed antigen in melanoma, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0030154 [cell differentiation]
GO:0040008 [regulation of growth]
GO:0042974 [retinoic acid receptor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0045596 [negative regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048387 [negative regulation of retinoic acid receptor signaling pathway]
Show all
 509 aa
57.9 kDa 		No 0
PRAME-005
ENSP00000407320
ENST00000439106
E7EW99 [Direct mapping]
Melanoma antigen preferentially-expressed in tumors
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 201 aa
23.1 kDa 		No 0
PRAME-006
ENSP00000384058
ENST00000406503
B5MCY4 [Direct mapping]
Melanoma antigen preferentially-expressed in tumors
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 115 aa
13.1 kDa 		No 0
PRAME-008
ENSP00000412318
ENST00000420709
E7EMH2 [Direct mapping]
Melanoma antigen preferentially-expressed in tumors
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 152 aa
17.5 kDa 		No 0
PRAME-009
ENSP00000385091
ENST00000403441
B5MD04 [Direct mapping]
Melanoma antigen preferentially-expressed in tumors
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
9.8 kDa 		No 0
PRAME-012
ENSP00000407121
ENST00000438888
H7C2P3 [Direct mapping]
Melanoma antigen preferentially-expressed in tumors
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 189 aa
21.1 kDa 		No 0
PRAME-201
ENSP00000381726
ENST00000398741
P78395 [Direct mapping]
Melanoma antigen preferentially expressed in tumors
A0A024R1E6 [Target identity:100%; Query identity:100%]
Preferentially expressed antigen in melanoma, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0030154 [cell differentiation]
GO:0040008 [regulation of growth]
GO:0042974 [retinoic acid receptor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0045596 [negative regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048387 [negative regulation of retinoic acid receptor signaling pathway]
Show all
 509 aa
57.9 kDa 		No 0
PRAME-202
ENSP00000445675
ENST00000543184
P78395 [Direct mapping]
Melanoma antigen preferentially expressed in tumors
A0A024R1E6 [Target identity:100%; Query identity:100%]
Preferentially expressed antigen in melanoma, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0030154 [cell differentiation]
GO:0040008 [regulation of growth]
GO:0042974 [retinoic acid receptor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0045596 [negative regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048387 [negative regulation of retinoic acid receptor signaling pathway]
Show all
 509 aa
57.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.