Expression of ADARB2 in cancer - Summary - The Human Protein Atlas

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ADARB2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADARB2
Gene description	Adenosine deaminase, RNA-specific, B2 (non-functional)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA031333
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031333

GENE INFORMATION
Gene name	ADARB2 (HGNC Symbol)
Synonyms	ADAR3, hRED2, RED2
Description	Adenosine deaminase, RNA-specific, B2 (non-functional) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	p15.3
Chromosome location (bp)	1177318 - 1737476
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185736 (version 83.38)
Entrez gene	105
UniProt	Q9NS39 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NS39
Antibodypedia	ADARB2 antibodies

PROTEIN BROWSER

ADARB2-001	ADARB2-002	ADARB2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADARB2-001 ENSP00000370713 ENST00000381312	Q9NS39 [Direct mapping] Double-stranded RNA-specific editase B2 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003723 [RNA binding] GO:0003725 [double-stranded RNA binding] GO:0003727 [single-stranded RNA binding] GO:0004000 [adenosine deaminase activity] GO:0005634 [nucleus] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	739 aa 80.6 kDa	No	0
ADARB2-002 ENSP00000370711 ENST00000381310	Q9NS39 [Direct mapping] Double-stranded RNA-specific editase B2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003723 [RNA binding] GO:0003725 [double-stranded RNA binding] GO:0003727 [single-stranded RNA binding] GO:0004000 [adenosine deaminase activity] GO:0005634 [nucleus] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	248 aa 26.7 kDa	No	0
ADARB2-005 ENSP00000370706 ENST00000381305	Q5VW43 [Direct mapping] Double-stranded RNA-specific editase B2 Show all	Predicted intracellular proteins Show all	GO:0003723 [RNA binding] GO:0004000 [adenosine deaminase activity] GO:0006396 [RNA processing] Show all	141 aa 15.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.