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KCNIP4

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GENERAL INFORMATION

Gene name

 KCNIP4

Gene description

 Kv channel interacting protein 4

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enhanced (RPTEC TERT1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA066717
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA066717 A-431 Vesicles
HPA066717 MCF7 Vesicles
HPA066717 U-2 OS Vesicles

GENE INFORMATION

Gene name

 KCNIP4 (HGNC Symbol)

Synonyms

 CALP, KCHIP4, MGC44947

Description

 Kv channel interacting protein 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

Chromosome location (bp)

 20728616 - 21948799

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185774 (version 83.38)

Entrez gene

 80333

UniProt

 Q6PIL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6PIL6

Antibodypedia

 KCNIP4 antibodies

PROTEIN BROWSER
KCNIP4-001
KCNIP4-002
KCNIP4-003
KCNIP4-004
KCNIP4-009
KCNIP4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNIP4-001
ENSP00000371583
ENST00000382148
Q6PIL6 [Direct mapping]
Kv channel-interacting protein 4
Show all
Transporters
   Transport Electron Carriers
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0071805 [potassium ion transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
Show all
 225 aa
26.3 kDa 		No 0
KCNIP4-002
ENSP00000371585
ENST00000382150
Q6PIL6 [Direct mapping]
Kv channel-interacting protein 4
Show all
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0071805 [potassium ion transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
Show all
 229 aa
26.5 kDa 		No 1
KCNIP4-003
ENSP00000399080
ENST00000447367
Q6PIL6 [Direct mapping]
Kv channel-interacting protein 4
Show all
Transporters
   Transport Electron Carriers
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0071805 [potassium ion transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
Show all
 216 aa
25 kDa 		No 0
KCNIP4-004
ENSP00000371587
ENST00000382152
Q6PIL6 [Direct mapping]
Kv channel-interacting protein 4
Show all
Transporters
   Transport Electron Carriers
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0071805 [potassium ion transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
Show all
 250 aa
28.7 kDa 		No 0
KCNIP4-009
ENSP00000423257
ENST00000509207
Q6PIL6 [Direct mapping]
Kv channel-interacting protein 4
Show all
Transporters
   Transport Electron Carriers
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0071805 [potassium ion transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
Show all
 188 aa
21.9 kDa 		No 0
KCNIP4-201
ENSP00000351892
ENST00000359001
Q6PIL6 [Direct mapping]
Kv channel-interacting protein 4
Show all
Transporters
   Transport Electron Carriers
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0071805 [potassium ion transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
Show all
 188 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.