Expression of PIGP in cancer - Summary - The Human Protein Atlas

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PIGP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PIGP
Gene description	Phosphatidylinositol glycan anchor biosynthesis, class P
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA026921
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026921

GENE INFORMATION
Gene name	PIGP (HGNC Symbol)
Synonyms	DCRC, DSCR5, DSRC
Description	Phosphatidylinositol glycan anchor biosynthesis, class P (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.13
Chromosome location (bp)	37059170 - 37073170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185808 (version 83.38)
Entrez gene	51227
UniProt	P57054 (UniProt - Evidence at protein level)
neXtProt	NX_P57054
Antibodypedia	PIGP antibodies

PROTEIN BROWSER

PIGP-001	PIGP-002	PIGP-003	PIGP-004	PIGP-005	PIGP-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGP-001 ENSP00000353719 ENST00000360525	P57054 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit P Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	134 aa 15.4 kDa	No	2
PIGP-002 ENSP00000382053 ENST00000399102	P57054 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit P Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	134 aa 15.4 kDa	No	2
PIGP-003 ENSP00000382049 ENST00000399098	P57054 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit P Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	108 aa 12.5 kDa	No	1
PIGP-004 ENSP00000420037 ENST00000464265	A0A0C4DH71 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit P Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005783 [endoplasmic reticulum] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] Show all	158 aa 18.1 kDa	Yes	2
PIGP-005 ENSP00000382054 ENST00000399103	P57054 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit P Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	134 aa 15.4 kDa	No	2
PIGP-007 ENSP00000388372 ENST00000430792	C9JKT1 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit P Show all	Predicted intracellular proteins Show all		25 aa 3 kDa	No	0

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