Expression of PCYT2 in cancer - Summary - The Human Protein Atlas

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PCYT2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PCYT2
Gene description	Phosphate cytidylyltransferase 2, ethanolamine
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA023033 , HPA023034
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023033	HPA023034

GENE INFORMATION
Gene name	PCYT2 (HGNC Symbol)
Synonyms	ET
Description	Phosphate cytidylyltransferase 2, ethanolamine (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81900965 - 81911464
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185813 (version 83.38)
Entrez gene	5833
UniProt	Q99447 (UniProt - Evidence at protein level)
neXtProt	NX_Q99447
Antibodypedia	PCYT2 antibodies

PROTEIN BROWSER

PCYT2-001	PCYT2-002	PCYT2-003	PCYT2-005	PCYT2-006	PCYT2-007	PCYT2-008	PCYT2-009	PCYT2-010	PCYT2-012	PCYT2-013	PCYT2-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCYT2-001 ENSP00000439245 ENST00000538936	Q99447 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004306 [ethanolamine-phosphate cytidylyltransferase activity] GO:0005575 [cellular_component] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	389 aa 43.8 kDa	No	0
PCYT2-002 ENSP00000459044 ENST00000571105	I3L1R7 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] Show all	367 aa 41.4 kDa	No	0
PCYT2-003 ENSP00000442050 ENST00000538721	Q99447 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004306 [ethanolamine-phosphate cytidylyltransferase activity] GO:0005575 [cellular_component] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	407 aa 45.6 kDa	No	0
PCYT2-005 ENSP00000458330 ENST00000570388	Q99447 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004306 [ethanolamine-phosphate cytidylyltransferase activity] GO:0005575 [cellular_component] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	311 aa 35.2 kDa	No	0
PCYT2-006 ENSP00000331719 ENST00000331285	Q99447 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004306 [ethanolamine-phosphate cytidylyltransferase activity] GO:0005575 [cellular_component] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	311 aa 35.2 kDa	No	0
PCYT2-007 ENSP00000461190 ENST00000570391	Q99447 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004306 [ethanolamine-phosphate cytidylyltransferase activity] GO:0005575 [cellular_component] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	357 aa 40.5 kDa	No	0
PCYT2-008 ENSP00000458805 ENST00000572473	I3L1F9 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] Show all	35 aa 4 kDa	No	0
PCYT2-009 ENSP00000458931 ENST00000576343	I3L1L9 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] Show all	314 aa 35.4 kDa	No	0
PCYT2-010 ENSP00000459836 ENST00000573636	I3L2Q1 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] Show all	286 aa 32 kDa	No	0
PCYT2-012 ENSP00000461814 ENST00000572157	I3NI16 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] Show all	53 aa 5.6 kDa	No	0
PCYT2-013 ENSP00000458727 ENST00000573927	I3L1C4 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] Show all	81 aa 9.1 kDa	No	0
PCYT2-014 ENSP00000460767 ENST00000572995	I3L3V9 [Direct mapping] Ethanolamine-phosphate cytidylyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] Show all	207 aa 23.2 kDa	No	0

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