Expression of EVI2B in cancer - Summary

GENERAL INFORMATION
Gene name	EVI2B
Gene description	Ecotropic viral integration site 2B
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HL-60, HMC-1, RPMI-8226, THP-1)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in a subset of lymphoid cells and neurons.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007436
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA007436

GENE INFORMATION
Gene name	EVI2B (HGNC Symbol)
Synonyms	CD361, D17S376, EVDB
Description	Ecotropic viral integration site 2B (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	31303766 - 31314112
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185862 (version 83.38)
Entrez gene	2124
UniProt	P34910 (UniProt - Evidence at protein level)
neXtProt	NX_P34910
Antibodypedia	EVI2B antibodies

PROTEIN BROWSER

EVI2B-001	EVI2B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EVI2B-001 ENSP00000333779 ENST00000330927	P34910 [Direct mapping] Protein EVI2B Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] Show all	448 aa 48.7 kDa	No	1
EVI2B-002 ENSP00000462682 ENST00000577894	P34910 [Direct mapping] Protein EVI2B Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] Show all	448 aa 48.7 kDa	No	1