Tissue expression of ATP6V0C - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ATP6V0C
Gene description	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Not detected
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ATP6V0C (HGNC Symbol)
Synonyms	ATP6C, ATP6L, ATPL, VATL, Vma3
Description	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c (HGNC Symbol)
Entrez gene summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2513870 - 2520218
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185883 (version 83.38)
Entrez gene	527
UniProt	P27449 (UniProt - Evidence at protein level)
neXtProt	NX_P27449
Antibodypedia	ATP6V0C antibodies

PROTEIN BROWSER

ATP6V0C-001	ATP6V0C-003	ATP6V0C-004	ATP6V0C-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6V0C-001 ENSP00000329757 ENST00000330398	P27449 [Direct mapping] V-type proton ATPase 16 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005925 [focal adhesion] GO:0006879 [cellular iron ion homeostasis] GO:0007042 [lysosomal lumen acidification] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030670 [phagocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0090382 [phagosome maturation] Show all	155 aa 15.7 kDa	No	3
ATP6V0C-003 ENSP00000454597 ENST00000568562	H3BMY0 [Direct mapping] V-type proton ATPase 16 kDa proteolipid subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.1 kDa	No	0
ATP6V0C-004 ENSP00000457782 ENST00000565223	H3BNI4 [Direct mapping] ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; V-type proton ATPase 16 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033179 [proton-transporting V-type ATPase, V0 domain] Show all	112 aa 11.6 kDa	No	3
ATP6V0C-005 ENSP00000454868 ENST00000564973	H3BNI4 [Direct mapping] ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; V-type proton ATPase 16 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033179 [proton-transporting V-type ATPase, V0 domain] Show all	112 aa 11.6 kDa	No	3