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IFITM1

GENERAL INFORMATION

Gene name

 IFITM1

Gene description

 Interferon induced transmembrane protein 1

Protein class

 CD markers
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct membranous expression in epididymis, also expressed in endothelial cells and in lymphoid tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004810 , CAB017615
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004810
CAB017615

GENE INFORMATION

Gene name

 IFITM1 (HGNC Symbol)

Synonyms

 9-27, CD225, IFI17

Description

 Interferon induced transmembrane protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 313506 - 315272

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185885 (version 83.38)

Entrez gene

 8519

UniProt

 P13164 (UniProt - Evidence at protein level)

neXtProt

 NX_P13164

Antibodypedia

 IFITM1 antibodies

PROTEIN BROWSER
IFITM1-001
IFITM1-002
IFITM1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFITM1-001
ENSP00000386187
ENST00000408968
P13164 [Direct mapping]
Interferon-induced transmembrane protein 1
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0001503 [ossification]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008285 [negative regulation of cell proliferation]
GO:0009607 [response to biotic stimulus]
GO:0009615 [response to virus]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030336 [negative regulation of cell migration]
GO:0034341 [response to interferon-gamma]
GO:0035455 [response to interferon-alpha]
GO:0035456 [response to interferon-beta]
GO:0035556 [intracellular signal transduction]
GO:0045071 [negative regulation of viral genome replication]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0050776 [regulation of immune response]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 125 aa
14 kDa 		No 2
IFITM1-002
ENSP00000437057
ENST00000528780
P13164 [Direct mapping]
Interferon-induced transmembrane protein 1
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Show all
GO:0001503 [ossification]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008285 [negative regulation of cell proliferation]
GO:0009607 [response to biotic stimulus]
GO:0009615 [response to virus]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030336 [negative regulation of cell migration]
GO:0034341 [response to interferon-gamma]
GO:0035455 [response to interferon-alpha]
GO:0035456 [response to interferon-beta]
GO:0035556 [intracellular signal transduction]
GO:0045071 [negative regulation of viral genome replication]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0050776 [regulation of immune response]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 125 aa
14 kDa 		No 2
IFITM1-003
ENSP00000330825
ENST00000328221
P13164 [Direct mapping]
Interferon-induced transmembrane protein 1
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Show all
GO:0001503 [ossification]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008285 [negative regulation of cell proliferation]
GO:0009607 [response to biotic stimulus]
GO:0009615 [response to virus]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030336 [negative regulation of cell migration]
GO:0034341 [response to interferon-gamma]
GO:0035455 [response to interferon-alpha]
GO:0035456 [response to interferon-beta]
GO:0035556 [intracellular signal transduction]
GO:0045071 [negative regulation of viral genome replication]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0050776 [regulation of immune response]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 125 aa
14 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.