Expression of FFAR3 in cancer - Summary

GENERAL INFORMATION
Gene name	FFAR3
Gene description	Free fatty acid receptor 3
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (adipose tissue, appendix, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Low membrane and cytoplasmic expression in most tissues, including the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA044681
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA044681

GENE INFORMATION
Gene name	FFAR3 (HGNC Symbol)
Synonyms	FFA3R, GPR41
Description	Free fatty acid receptor 3 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35358460 - 35360485
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185897 (version 83.38)
Entrez gene	2865
UniProt	O14843 (UniProt - Evidence at protein level)
neXtProt	NX_O14843
Antibodypedia	FFAR3 antibodies

PROTEIN BROWSER

FFAR3-001	FFAR3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FFAR3-001 ENSP00000328230 ENST00000327809	O14843 [Direct mapping] Free fatty acid receptor 3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002385 [mucosal immune response] GO:0002720 [positive regulation of cytokine production involved in immune response] GO:0002879 [positive regulation of acute inflammatory response to non-antigenic stimulus] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0008289 [lipid binding] GO:0014061 [regulation of norepinephrine secretion] GO:0016021 [integral component of membrane] GO:0032722 [positive regulation of chemokine production] GO:0045776 [negative regulation of blood pressure] GO:0046885 [regulation of hormone biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0090276 [regulation of peptide hormone secretion] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	346 aa 38.6 kDa	No	7
FFAR3-002 ENSP00000469522 ENST00000594310	O14843 [Direct mapping] Free fatty acid receptor 3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002385 [mucosal immune response] GO:0002720 [positive regulation of cytokine production involved in immune response] GO:0002879 [positive regulation of acute inflammatory response to non-antigenic stimulus] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0008289 [lipid binding] GO:0014061 [regulation of norepinephrine secretion] GO:0016021 [integral component of membrane] GO:0032722 [positive regulation of chemokine production] GO:0045776 [negative regulation of blood pressure] GO:0046885 [regulation of hormone biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0090276 [regulation of peptide hormone secretion] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	346 aa 38.6 kDa	No	7