Cell atlas - POMK - The Human Protein Atlas

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POMK

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	POMK
Gene description	Protein-O-mannose kinase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA013321
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA013321	A-431	Nucleus
	HPA013321	A-431	Cytosol
	HPA013321	U-251 MG	Nucleus
	HPA013321	U-251 MG	Cytosol

GENE INFORMATION
Gene name	POMK (HGNC Symbol)
Synonyms	FLJ23356, SgK196
Description	Protein-O-mannose kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	43093506 - 43123434
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185900 (version 83.38)
Entrez gene	84197
UniProt	Q9H5K3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H5K3
Antibodypedia	POMK antibodies

PROTEIN BROWSER

POMK-001	POMK-002	POMK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POMK-001 ENSP00000331258 ENST00000331373	Q9H5K3 [Direct mapping] Protein O-mannose kinase Show all	Enzymes ENZYME proteins Transferases Kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006468 [protein phosphorylation] GO:0006493 [protein O-linked glycosylation] GO:0007420 [brain development] GO:0007611 [learning or memory] GO:0016021 [integral component of membrane] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0019200 [carbohydrate kinase activity] GO:0019233 [sensory perception of pain] GO:0046835 [carbohydrate phosphorylation] GO:0050905 [neuromuscular process] Show all	350 aa 40 kDa	No	1
POMK-002 ENSP00000429090 ENST00000518991	E5RJD5 [Direct mapping] Protein O-mannose kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	134 aa 15.4 kDa	No	1
POMK-201 ENSP00000478821 ENST00000614426	Q9H5K3 [Direct mapping] Protein O-mannose kinase Show all	Enzymes ENZYME proteins Transferases Kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006468 [protein phosphorylation] GO:0006493 [protein O-linked glycosylation] GO:0007420 [brain development] GO:0016021 [integral component of membrane] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0019200 [carbohydrate kinase activity] GO:0046835 [carbohydrate phosphorylation] Show all	350 aa 40 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.