Expression of KLHDC8B in cancer - Summary - The Human Protein Atlas

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KLHDC8B

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KLHDC8B
Gene description	Kelch domain containing 8B
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA008463 , HPA014467
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008463	HPA014467

GENE INFORMATION
Gene name	KLHDC8B (HGNC Symbol)
Synonyms	MGC35097
Description	Kelch domain containing 8B (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49171611 - 49176486
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185909 (version 83.38)
Entrez gene	200942
UniProt	Q8IXV7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IXV7
Antibodypedia	KLHDC8B antibodies

PROTEIN BROWSER

KLHDC8B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHDC8B-001 ENSP00000327468 ENST00000332780	Q8IXV7 [Direct mapping] Kelch domain-containing protein 8B A0A024R2X4 [Target identity:100%; Query identity:100%] Kelch domain containing 8B, isoform CRA_b Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	354 aa 37.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.