Expression of SETD4 in cancer - Summary - The Human Protein Atlas

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SETD4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SETD4
Gene description	SET domain containing 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA024073
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024073

GENE INFORMATION
Gene name	SETD4 (HGNC Symbol)
Synonyms	C21orf18, C21orf27
Description	SET domain containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	21
Cytoband	q22.12
Chromosome location (bp)	36034541 - 36079389
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185917 (version 83.38)
Entrez gene	54093
UniProt	Q9NVD3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NVD3
Antibodypedia	SETD4 antibodies

PROTEIN BROWSER

SETD4-001	SETD4-003	SETD4-004	SETD4-005	SETD4-006	SETD4-007	SETD4-009	SETD4-010	SETD4-011	SETD4-012	SETD4-013	SETD4-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SETD4-001 ENSP00000329189 ENST00000332131	Q9NVD3 [Direct mapping] SET domain-containing protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0016279 [protein-lysine N-methyltransferase activity] GO:0018023 [peptidyl-lysine trimethylation] GO:0018026 [peptidyl-lysine monomethylation] GO:0042254 [ribosome biogenesis] Show all	440 aa 50.4 kDa	No	0
SETD4-003 ENSP00000382161 ENST00000399212	Q9NVD3 [Direct mapping] SET domain-containing protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0016279 [protein-lysine N-methyltransferase activity] GO:0018023 [peptidyl-lysine trimethylation] GO:0018026 [peptidyl-lysine monomethylation] GO:0042254 [ribosome biogenesis] Show all	416 aa 47.7 kDa	No	0
SETD4-004 ENSP00000382156 ENST00000399205	A8MTS1 [Direct mapping] SET domain-containing protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	283 aa 32.4 kDa	No	0
SETD4-005 ENSP00000382163 ENST00000399215	Q9NVD3 [Direct mapping] SET domain-containing protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0016279 [protein-lysine N-methyltransferase activity] GO:0018023 [peptidyl-lysine trimethylation] GO:0018026 [peptidyl-lysine monomethylation] GO:0042254 [ribosome biogenesis] Show all	440 aa 50.4 kDa	No	0
SETD4-006 ENSP00000382159 ENST00000399208	Q9NVD3 [Direct mapping] SET domain-containing protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0016279 [protein-lysine N-methyltransferase activity] GO:0018023 [peptidyl-lysine trimethylation] GO:0018026 [peptidyl-lysine monomethylation] GO:0042254 [ribosome biogenesis] Show all	307 aa 35.1 kDa	No	0
SETD4-007 ENSP00000382152 ENST00000399201	A8MTS1 [Direct mapping] SET domain-containing protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	283 aa 32.4 kDa	No	0
SETD4-009 ENSP00000413318 ENST00000446166	C9JYV0 [Direct mapping] SET domain-containing protein 4 Show all	Predicted intracellular proteins Show all		124 aa 14 kDa	No	0
SETD4-010 ENSP00000396837 ENST00000429161	C9JIU9 [Direct mapping] SET domain-containing protein 4 Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		225 aa 25.5 kDa	No	0
SETD4-011 ENSP00000382158 ENST00000399207	Q9NVD3 [Direct mapping] SET domain-containing protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0016279 [protein-lysine N-methyltransferase activity] GO:0018023 [peptidyl-lysine trimethylation] GO:0018026 [peptidyl-lysine monomethylation] GO:0042254 [ribosome biogenesis] Show all	307 aa 35.1 kDa	No	0
SETD4-012 ENSP00000392463 ENST00000443703	C9J256 [Direct mapping] SET domain-containing protein 4 Show all	Predicted intracellular proteins Show all		67 aa 7.6 kDa	No	0
SETD4-013 ENSP00000399998 ENST00000424303	C9JWV5 [Direct mapping] SET domain-containing protein 4 Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		231 aa 26.1 kDa	No	0
SETD4-014 ENSP00000394822 ENST00000442559	C9JPA1 [Direct mapping] SET domain-containing protein 4 Show all	Predicted intracellular proteins Show all		70 aa 7.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.