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BICD2

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GENERAL INFORMATION

Gene name

 BICD2

Gene description

 Bicaudal D homolog 2 (Drosophila)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane, cytosol & the Golgi apparatus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (supported), Plasma membrane (uncertain), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA023013
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane, cytosol & the Golgi apparatus.

Main location

 Golgi apparatus (supported), Plasma membrane (uncertain), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023013 A-431 Golgi apparatus
Cytosol
HPA023013 U-2 OS Plasma membrane
Cytosol
HPA023013 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 BICD2 (HGNC Symbol)

Synonyms

 KIAA0699

Description

 Bicaudal D homolog 2 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.31

Chromosome location (bp)

 92711363 - 92764812

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185963 (version 83.38)

Entrez gene

 23299

UniProt

 Q8TD16 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TD16

Antibodypedia

 BICD2 antibodies

PROTEIN BROWSER
BICD2-001
BICD2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BICD2-001
ENSP00000349351
ENST00000356884
Q8TD16 [Direct mapping]
Protein bicaudal D homolog 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007018 [microtubule-based movement]
GO:0017137 [Rab GTPase binding]
GO:0031410 [cytoplasmic vesicle]
GO:0072385 [minus-end-directed organelle transport along microtubule]
GO:0072393 [microtubule anchoring at microtubule organizing center]
Show all
 855 aa
96.8 kDa 		No 0
BICD2-002
ENSP00000364662
ENST00000375512
Q8TD16 [Direct mapping]
Protein bicaudal D homolog 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0017137 [Rab GTPase binding]
GO:0031410 [cytoplasmic vesicle]
GO:0072385 [minus-end-directed organelle transport along microtubule]
GO:0072393 [microtubule anchoring at microtubule organizing center]
Show all
 824 aa
93.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.