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A majority of cancer cells showed moderate cytoplasmic staining with additional nucleolar positivity in several cases. Several cases of hepatocellular carcinomas along with a few cases of lymphomas and thyroid cancers exhibited strong immunoreactivity.
GENE INFORMATION
Gene name
RASA3 (HGNC Symbol)
Synonyms
GAP1IP4BP, GAPIII
Description
RAS p21 protein activator 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. [provided by RefSeq, Jul 2008]