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KRT73

GENERAL INFORMATION

Gene name

 KRT73

Gene description

 Keratin 73, type II

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (lymph node, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Highly expressed in the inner root sheath of hair.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with external characterization data and GTEx RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044031
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA044031

GENE INFORMATION

Gene name

 KRT73 (HGNC Symbol)

Synonyms

 K6IRS3, KRT6IRS3

Description

 Keratin 73, type II (HGNC Symbol)

Entrez gene summary

 Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52607570 - 52618559

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186049 (version 83.38)

Entrez gene

 319101

UniProt

 Q86Y46 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86Y46

Antibodypedia

 KRT73 antibodies

PROTEIN BROWSER
KRT73-001
KRT73-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT73-001
ENSP00000307014
ENST00000305748
Q86Y46 [Direct mapping]
Keratin, type II cytoskeletal 73
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005882 [intermediate filament]
GO:0008150 [biological_process]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 540 aa
58.9 kDa 		No 0
KRT73-003
ENSP00000449081
ENST00000552855
H0YIC5 [Direct mapping]
Keratin, type II cytoskeletal 73
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 285 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.