Expression of AGBL4 in cancer - Summary

GENERAL INFORMATION
Gene name	AGBL4
Gene description	ATP/GTP binding protein-like 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (NTERA-2, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including CNS, cilia in fallopian tube and respiratory tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA037994
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA037994

GENE INFORMATION
Gene name	AGBL4 (HGNC Symbol)
Synonyms	CCP6, FLJ14442
Description	ATP/GTP binding protein-like 4 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p33
Chromosome location (bp)	48532855 - 50023913
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000186094 (version 83.38)
Entrez gene	84871
UniProt	Q5VU57 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VU57
Antibodypedia	AGBL4 antibodies

PROTEIN BROWSER

AGBL4-001	AGBL4-002	AGBL4-003	AGBL4-004	AGBL4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGBL4-001 ENSP00000360905 ENST00000371839	Q5VU57 [Direct mapping] Cytosolic carboxypeptidase 6 Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0015631 [tubulin binding] GO:0035609 [C-terminal protein deglutamylation] GO:0035610 [protein side chain deglutamylation] GO:0036064 [ciliary basal body] Show all	503 aa 58.2 kDa	No	0
AGBL4-002 ENSP00000401622 ENST00000416121	H0Y5X4 [Direct mapping] Cytosolic carboxypeptidase 6 Show all	Predicted intracellular proteins Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	299 aa 34.3 kDa	No	0
AGBL4-003 ENSP00000360902 ENST00000371836	B1ANV5 [Direct mapping] Cytosolic carboxypeptidase 6 Show all	Predicted intracellular proteins Show all		217 aa 25.5 kDa	No	0
AGBL4-004 ENSP00000360904 ENST00000371838	B1AMW3 [Direct mapping] Cytosolic carboxypeptidase 6 Show all	Predicted intracellular proteins Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	320 aa 37.1 kDa	No	0
AGBL4-201 ENSP00000335516 ENST00000334103	F8VWL7 [Direct mapping] Cytosolic carboxypeptidase 6 Show all	Predicted intracellular proteins Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	292 aa 33.4 kDa	No	0