Expression of ANKRD46 in cancer - Summary - The Human Protein Atlas

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ANKRD46

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKRD46
Gene description	Ankyrin repeat domain 46
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA013758
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013758

GENE INFORMATION
Gene name	ANKRD46
Synonyms
Description	Ankyrin repeat domain 46 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	100509752 - 100559784
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186106 (version 83.38)
Entrez gene	157567
UniProt	Q86W74 (UniProt - Evidence at protein level)
neXtProt	NX_Q86W74
Antibodypedia	ANKRD46 antibodies

PROTEIN BROWSER

ANKRD46-001	ANKRD46-002	ANKRD46-004	ANKRD46-005	ANKRD46-006	ANKRD46-007	ANKRD46-008	ANKRD46-010	ANKRD46-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD46-001 ENSP00000335287 ENST00000335659	Q86W74 [Direct mapping] Ankyrin repeat domain-containing protein 46 A0A024R9E1 [Target identity:100%; Query identity:100%] Ankyrin repeat domain 46, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	228 aa 25.3 kDa	No	1
ANKRD46-002 ENSP00000428388 ENST00000520311	Q86W74 [Direct mapping] Ankyrin repeat domain-containing protein 46 A0A024R9E1 [Target identity:100%; Query identity:100%] Ankyrin repeat domain 46, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	228 aa 25.3 kDa	No	1
ANKRD46-004 ENSP00000429015 ENST00000520552	Q86W74 [Direct mapping] Ankyrin repeat domain-containing protein 46 A0A024R9G2 [Target identity:100%; Query identity:100%] Ankyrin repeat domain 46, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	232 aa 26 kDa	No	1
ANKRD46-005 ENSP00000430056 ENST00000519597	Q86W74 [Direct mapping] Ankyrin repeat domain-containing protein 46 A0A024R9E1 [Target identity:100%; Query identity:100%] Ankyrin repeat domain 46, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	228 aa 25.3 kDa	No	1
ANKRD46-006 ENSP00000351881 ENST00000358990	J3KP26 [Direct mapping] Ankyrin repeat domain-containing protein 46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	195 aa 21.7 kDa	No	0
ANKRD46-007 ENSP00000430800 ENST00000523000	E5RI20 [Direct mapping] Ankyrin repeat domain-containing protein 46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	86 aa 9.4 kDa	No	0
ANKRD46-008 ENSP00000429647 ENST00000521345	E5RHV2 [Direct mapping] Ankyrin repeat domain-containing protein 46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	82 aa 9 kDa	No	0
ANKRD46-010 ENSP00000430357 ENST00000524072	E5RFM7 [Direct mapping] Ankyrin repeat domain-containing protein 46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	103 aa 11.3 kDa	No	0
ANKRD46-011 ENSP00000430827 ENST00000519316	E5RI04 [Direct mapping] Ankyrin repeat domain-containing protein 46 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	175 aa 19.4 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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