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CYP4F2

GENERAL INFORMATION

Gene name

 CYP4F2

Gene description

 Cytochrome P450, family 4, subfamily F, polypeptide 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, epididymis, kidney, liver, small intestine)
GTEx:Group enriched (liver, small intestine)
FANTOM5:Group enriched (liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in liver, small intestines and kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA014048 , HPA017265 , HPA058960
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, epididymis, kidney, liver, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine)

GENE INFORMATION

Gene name

 CYP4F2

Synonyms

Description

 Cytochrome P450, family 4, subfamily F, polypeptide 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 15878023 - 15898120

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186115 (version 83.38)

Entrez gene

 8529

UniProt

 P78329 (UniProt - Evidence at protein level)

neXtProt

 NX_P78329

Antibodypedia

 CYP4F2 antibodies

PROTEIN BROWSER
CYP4F2-001
CYP4F2-005
CYP4F2-007
CYP4F2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP4F2-001
ENSP00000221700
ENST00000221700
P78329 [Direct mapping]
Phylloquinone omega-hydroxylase CYP4F2
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003091 [renal water homeostasis]
GO:0003095 [pressure natriuresis]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006690 [icosanoid metabolic process]
GO:0006691 [leukotriene metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007596 [blood coagulation]
GO:0008217 [regulation of blood pressure]
GO:0008392 [arachidonic acid epoxygenase activity]
GO:0016324 [apical plasma membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0017144 [drug metabolic process]
GO:0018685 [alkane 1-monooxygenase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0020037 [heme binding]
GO:0032304 [negative regulation of icosanoid secretion]
GO:0032305 [positive regulation of icosanoid secretion]
GO:0036101 [leukotriene B4 catabolic process]
GO:0042360 [vitamin E metabolic process]
GO:0042361 [menaquinone catabolic process]
GO:0042376 [phylloquinone catabolic process]
GO:0042377 [vitamin K catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0050051 [leukotriene-B4 20-monooxygenase activity]
GO:0052869 [arachidonic acid omega-hydroxylase activity]
GO:0052871 [alpha-tocopherol omega-hydroxylase activity]
GO:0052872 [tocotrienol omega-hydroxylase activity]
GO:0055078 [sodium ion homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0097267 [omega-hydroxylase P450 pathway]
Show all
 520 aa
59.9 kDa 		Yes 0
CYP4F2-005
ENSP00000465514
ENST00000586927
K7EK90 [Direct mapping]
Phylloquinone omega-hydroxylase CYP4F2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 154 aa
17.6 kDa 		No 1
CYP4F2-007
ENSP00000467846
ENST00000589654
K7EQI8 [Direct mapping]
Phylloquinone omega-hydroxylase CYP4F2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 74 aa
8.9 kDa 		No 0
CYP4F2-201
ENSP00000011989
ENST00000011989
A0A0A0MQR0 [Direct mapping]
Cytochrome P450, family 4, subfamily F, polypeptide 2, isoform CRA_a; Phylloquinone omega-hydroxylase CYP4F2
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 520 aa
59.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.