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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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POLR3C
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

POLR3C

Gene description

Polymerase (RNA) III (DNA directed) polypeptide C (62kD)

Protein class

Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA027508
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), melanoma (unfavourable), endometrial cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Melanoma p<0.001
Endometrial cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY

HPA027508

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate nuclear and cytoplasmic immunoreactivity was expressed in breast, skin, thyroid, and urothelial cancers. Most remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

POLR3C (HGNC Symbol)

Synonyms

RPC3, RPC62

Description

Polymerase (RNA) III (DNA directed) polypeptide C (62kD) (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

q21.1

Chromosome location (bp)

145824088 - 145842505

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186141 (version 83.38)

Entrez gene

10623

UniProt

Q9BUI4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BUI4

Antibodypedia

POLR3C antibodies

PROTEIN BROWSER

POLR3C-001
POLR3C-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POLR3C-001
ENSP00000334564
ENST00000334163
Q9BUI4 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC3
A0A024R4C1 [Target identity:100%; Query identity:100%]
Polymerase (RNA) III (DNA directed) polypeptide C (62kD), isoform CRA_b
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006359 [regulation of transcription from RNA polymerase III promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0051607 [defense response to virus]
Show all
534 aa
60.6 kDa
No 0
POLR3C-002
ENSP00000358300
ENST00000369294
E9PHH9 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC3
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
411 aa
46.2 kDa
No 0

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