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POLR1D

GENERAL INFORMATION

Gene name

 POLR1D

Gene description

 Polymerase (RNA) I polypeptide D, 16kDa

Protein class

 Disease related genes
Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA039337
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039337

GENE INFORMATION

Gene name

 POLR1D (HGNC Symbol)

Synonyms

 MGC9850, RPA16, RPA9, RPAC2, RPO1-3

Description

 Polymerase (RNA) I polypeptide D, 16kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]

Chromosome

 13

Cytoband

 q12.2

Chromosome location (bp)

 27620742 - 27667415

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186184 (version 83.38)

Entrez gene

 51082

UniProt

 Q9Y2S0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2S0

Antibodypedia

 POLR1D antibodies

PROTEIN BROWSER
POLR1D-001
POLR1D-003
POLR1D-004
POLR1D-005
POLR1D-006
POLR1D-009
POLR1D-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR1D-001
ENSP00000483656
ENST00000489647
A0A087X0U2 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC2; HCG2020048, isoform CRA_c
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
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 42 aa
4.8 kDa 		No 0
POLR1D-003
ENSP00000302478
ENST00000302979
Q9Y2S0 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC2
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Predicted intracellular proteins
RNA polymerase related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046983 [protein dimerization activity]
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 133 aa
15.2 kDa 		No 0
POLR1D-004
ENSP00000382604
ENST00000399697
Q9Y2S0 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC2
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Predicted intracellular proteins
RNA polymerase related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046983 [protein dimerization activity]
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 122 aa
14.3 kDa 		No 0
POLR1D-005
ENSP00000486928
ENST00000630983
Q7Z776 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC2; POLR1D protein
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 33 aa
3.8 kDa 		No 0
POLR1D-006
ENSP00000478213
ENST00000621089
A0A087WTY1 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC2
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 94 aa
11 kDa 		No 0
POLR1D-009
ENSP00000486327
ENST00000627604
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
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 3 aa
0.3 kDa 		No 0
POLR1D-012
ENSP00000382603
ENST00000399696
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 116 aa
13.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.