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MKL2

GENERAL INFORMATION

Gene name

 MKL2

Gene description

 MKL/myocardin-like 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA011286
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011286

GENE INFORMATION

Gene name

 MKL2 (HGNC Symbol)

Synonyms

 FLJ31823, MRTF-B

Description

 MKL/myocardin-like 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 p13.12

Chromosome location (bp)

 14071321 - 14266773

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186260 (version 83.38)

Entrez gene

 57496

UniProt

 Q9ULH7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULH7

Antibodypedia

 MKL2 antibodies

PROTEIN BROWSER
MKL2-001
MKL2-002
MKL2-004
MKL2-005
MKL2-007
MKL2-010
MKL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MKL2-001
ENSP00000459626
ENST00000571589
Q9ULH7 [Direct mapping]
MKL/myocardin-like protein 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001701 [in utero embryonic development]
GO:0001889 [liver development]
GO:0003007 [heart morphogenesis]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0045844 [positive regulation of striated muscle tissue development]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048514 [blood vessel morphogenesis]
GO:0048568 [embryonic organ development]
GO:0048738 [cardiac muscle tissue development]
GO:0051145 [smooth muscle cell differentiation]
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 1099 aa
119.2 kDa 		No 0
MKL2-002
ENSP00000459205
ENST00000574045
Q9ULH7 [Direct mapping]
MKL/myocardin-like protein 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0045844 [positive regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051145 [smooth muscle cell differentiation]
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 1049 aa
114.1 kDa 		No 0
MKL2-004
ENSP00000459879
ENST00000572567
I3L2S3 [Direct mapping]
Phosphatase and actin regulator
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0043086 [negative regulation of catalytic activity]
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 369 aa
41.4 kDa 		No 0
MKL2-005
ENSP00000460589
ENST00000573051
Q9ULH7 [Direct mapping]
MKL/myocardin-like protein 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0045844 [positive regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051145 [smooth muscle cell differentiation]
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 378 aa
42.5 kDa 		No 0
MKL2-007
ENSP00000458340
ENST00000574998
I3L0U1 [Direct mapping]
MKL/myocardin-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 70 aa
7.9 kDa 		No 0
MKL2-010
ENSP00000460848
ENST00000573434
I3L3Z7 [Direct mapping]
MKL/myocardin-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 52 aa
5.7 kDa 		No 0
MKL2-201
ENSP00000339086
ENST00000318282
Q9ULH7 [Direct mapping]
MKL/myocardin-like protein 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0045844 [positive regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051145 [smooth muscle cell differentiation]
Show all
 1049 aa
114.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.