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BTLA

GENERAL INFORMATION

Gene name

 BTLA

Gene description

 B and T lymphocyte associated

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (appendix, lymph node, spleen, tonsil)
GTEx:Group enriched (small intestine, spleen)
FANTOM5:Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA047211 , HPA062029
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, lymph node, spleen, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, lymph node, spleen, tonsil)

GENE INFORMATION

Gene name

 BTLA (HGNC Symbol)

Synonyms

 BTLA1, CD272

Description

 B and T lymphocyte associated (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

Chromosome

 3

Cytoband

 q13.2

Chromosome location (bp)

 112463968 - 112499561

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186265 (version 83.38)

Entrez gene

 151888

UniProt

 Q7Z6A9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z6A9

Antibodypedia

 BTLA antibodies

PROTEIN BROWSER
BTLA-001
BTLA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BTLA-001
ENSP00000333919
ENST00000334529
Q7Z6A9 [Direct mapping]
B- and T-lymphocyte attenuator
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031295 [T cell costimulation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0046642 [negative regulation of alpha-beta T cell proliferation]
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 289 aa
32.8 kDa 		No 1
BTLA-002
ENSP00000373178
ENST00000383680
Q7Z6A9 [Direct mapping]
B- and T-lymphocyte attenuator
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CD markers
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0031295 [T cell costimulation]
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 241 aa
27.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.