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Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0001889 [liver development] GO:0001890 [placenta development] GO:0001893 [maternal placenta development] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0003708 [retinoic acid receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004886 [9-cis retinoic acid receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006766 [vitamin metabolic process] GO:0006954 [inflammatory response] GO:0007494 [midgut development] GO:0007565 [female pregnancy] GO:0007566 [embryo implantation] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008203 [cholesterol metabolic process] GO:0008206 [bile acid metabolic process] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010269 [response to selenium ion] GO:0010467 [gene expression] GO:0014070 [response to organic cyclic compound] GO:0015721 [bile acid and bile salt transport] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030424 [axon] GO:0031103 [axon regeneration] GO:0031490 [chromatin DNA binding] GO:0031641 [regulation of myelination] GO:0032403 [protein complex binding] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033189 [response to vitamin A] GO:0033280 [response to vitamin D] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042809 [vitamin D receptor binding] GO:0042974 [retinoic acid receptor binding] GO:0043010 [camera-type eye development] GO:0043065 [positive regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044323 [retinoic acid-responsive element binding] GO:0045471 [response to ethanol] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045994 [positive regulation of translational initiation by iron] GO:0046982 [protein heterodimerization activity] GO:0048384 [retinoic acid receptor signaling pathway] GO:0051289 [protein homotetramerization] GO:0051384 [response to glucocorticoid] GO:0055010 [ventricular cardiac muscle tissue morphogenesis] GO:0055012 [ventricular cardiac muscle cell differentiation] GO:0060528 [secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development] GO:0060687 [regulation of branching involved in prostate gland morphogenesis] GO:0070644 [vitamin D response element binding] GO:0090575 [RNA polymerase II transcription factor complex] GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]