Expression of CYP4X1 in cancer - Summary - The Human Protein Atlas

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CYP4X1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CYP4X1
Gene description	Cytochrome P450, family 4, subfamily X, polypeptide 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CACO-2, SCLC-21H, T-47d)
HPA (normal tissue):	Tissue enhanced (cervix, uterine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, including cervix, uterine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA017661
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017661

GENE INFORMATION
Gene name	CYP4X1 (HGNC Symbol)
Synonyms	MGC40051
Description	Cytochrome P450, family 4, subfamily X, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p33
Chromosome location (bp)	47023568 - 47050751
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186377 (version 83.38)
Entrez gene	260293
UniProt	Q8N118 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N118
Antibodypedia	CYP4X1 antibodies

PROTEIN BROWSER

CYP4X1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP4X1-001 ENSP00000360968 ENST00000371901	Q8N118 [Direct mapping] Cytochrome P450 4X1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	509 aa 58.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.