Expression of KRT26 in cancer - Summary - The Human Protein Atlas

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KRT26

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT26
Gene description	Keratin 26, type I
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in the inner root sheath of hair follicles.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with external characterization data and GTEx RNA expression data.
Reliability score	Supported based on 1 antibody. HPA026890
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026890

GENE INFORMATION
Gene name	KRT26 (HGNC Symbol)
Synonyms	KRT25B
Description	Keratin 26, type I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	40766238 - 40772162
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186393 (version 83.38)
Entrez gene	353288
UniProt	Q7Z3Y9 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z3Y9
Antibodypedia	KRT26 antibodies

PROTEIN BROWSER

KRT26-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT26-001 ENSP00000334798 ENST00000335552	Q7Z3Y9 [Direct mapping] Keratin, type I cytoskeletal 26 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] GO:0070062 [extracellular exosome] Show all	468 aa 51.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.