Expression of CD300E in cancer - Summary - The Human Protein Atlas

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CD300E

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD300E
Gene description	CD300e molecule
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (appendix, bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA015570
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015570

GENE INFORMATION
Gene name	CD300E (HGNC Symbol)
Synonyms	CD300LE, CLM2, IREM2
Description	CD300e molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	74609887 - 74623738
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186407 (version 83.38)
Entrez gene	342510
UniProt	Q496F6 (UniProt - Evidence at protein level)
neXtProt	NX_Q496F6
Antibodypedia	CD300E antibodies

PROTEIN BROWSER

CD300E-001	CD300E-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD300E-001 ENSP00000376395 ENST00000392619	Q496F6 [Direct mapping] CMRF35-like molecule 2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	205 aa 22.9 kDa	Yes	1
CD300E-002 ENSP00000415488 ENST00000412268	C9JDD2 [Direct mapping] CMRF35-like molecule 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	122 aa 13.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.