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NKRF

GENERAL INFORMATION

Gene name

 NKRF

Gene description

 NFKB repressing factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 NKRF (HGNC Symbol)

Synonyms

 ITBA4, NRF

Description

 NFKB repressing factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 q24

Chromosome location (bp)

 119588337 - 119605895

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186416 (version 83.38)

Entrez gene

 55922

UniProt

 O15226 (UniProt - Evidence at protein level)

neXtProt

 NX_O15226

Antibodypedia

 NKRF antibodies

PROTEIN BROWSER
NKRF-001
NKRF-002
NKRF-201
NKRF-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKRF-001
ENSP00000360582
ENST00000371527
O15226 [Direct mapping]
NF-kappa-B-repressing factor
A3F769 [Target identity:100%; Query identity:100%]
NF-kappaB repressing factor; NF-kappaB repressing factor, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005783 [endoplasmic reticulum]
GO:0006351 [transcription, DNA-templated]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
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 690 aa
77.7 kDa 		No 0
NKRF-002
ENSP00000304803
ENST00000304449
O15226 [Direct mapping]
NF-kappa-B-repressing factor
A3F769 [Target identity:100%; Query identity:100%]
NF-kappaB repressing factor; NF-kappaB repressing factor, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005783 [endoplasmic reticulum]
GO:0006351 [transcription, DNA-templated]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 690 aa
77.7 kDa 		No 0
NKRF-201
ENSP00000442308
ENST00000542113
O15226 [Direct mapping]
NF-kappa-B-repressing factor
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005783 [endoplasmic reticulum]
GO:0006351 [transcription, DNA-templated]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 705 aa
79.5 kDa 		No 0
NKRF-202
ENSP00000481262
ENST00000617452
A0A087WXT2 [Direct mapping]
NF-kappa-B-repressing factor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 387 aa
43.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.