Expression of FCAR in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FCAR
Gene description	Fc fragment of IgA receptor
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in a subset of inflammatory cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA014050
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA014050

GENE INFORMATION
Gene name	FCAR (HGNC Symbol)
Synonyms	CD89
Description	Fc fragment of IgA receptor (HGNC Symbol)
Entrez gene summary	This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	54874248 - 54890472
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186431 (version 83.38)
Entrez gene	2204
UniProt	P24071 (UniProt - Evidence at protein level)
neXtProt	NX_P24071
Antibodypedia	FCAR antibodies

PROTEIN BROWSER

FCAR-001	FCAR-002	FCAR-003	FCAR-004	FCAR-005	FCAR-006	FCAR-007	FCAR-008	FCAR-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCAR-001 ENSP00000347714 ENST00000355524	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019862 [IgA binding] Show all	287 aa 32.3 kDa	Yes	1
FCAR-002 ENSP00000375605 ENST00000391725	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor A0A024R4N4 [Target identity:100%; Query identity:100%] Fc of IgA, receptor for, isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0019862 [IgA binding] Show all	265 aa 29.7 kDa	Yes	1
FCAR-003 ENSP00000338257 ENST00000345937	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0019862 [IgA binding] Show all	191 aa 21.7 kDa	Yes	1
FCAR-004 ENSP00000338058 ENST00000353758	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0019862 [IgA binding] Show all	178 aa 19.6 kDa	No	1
FCAR-005 ENSP00000352218 ENST00000359272	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0019862 [IgA binding] Show all	275 aa 30.9 kDa	No	1
FCAR-006 ENSP00000473814 ENST00000469767	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor A0A024R4M5 [Target identity:100%; Query identity:100%] Fc of IgA, receptor for, isoform CRA_f Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0019862 [IgA binding] Show all	239 aa 27 kDa	Yes	0
FCAR-007 ENSP00000375603 ENST00000391723	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor Show all	CD markers Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0019862 [IgA binding] Show all	209 aa 23.4 kDa	No	0
FCAR-008 ENSP00000375604 ENST00000391724	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor A0A024R4R4 [Target identity:100%; Query identity:100%] Fc of IgA, receptor for, isoform CRA_i Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0019862 [IgA binding] Show all	253 aa 28.3 kDa	No	1
FCAR-009 ENSP00000375606 ENST00000391726	P24071 [Direct mapping] Immunoglobulin alpha Fc receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0019862 [IgA binding] Show all	179 aa 20.4 kDa	No	1