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KPNA4

GENERAL INFORMATION

Gene name

 KPNA4

Gene description

 Karyopherin alpha 4 (importin alpha 3)

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA043154 , HPA045500 , CAB034336
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043154
HPA045500
CAB034336

GENE INFORMATION

Gene name

 KPNA4 (HGNC Symbol)

Synonyms

 IPOA3, MGC12217, MGC26703, QIP1, SRP3

Description

 Karyopherin alpha 4 (importin alpha 3) (HGNC Symbol)

Entrez gene summary

 The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q25.33

Chromosome location (bp)

 160494995 - 160565588

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186432 (version 83.38)

Entrez gene

 3840

UniProt

 O00629 (UniProt - Evidence at protein level)

neXtProt

 NX_O00629

Antibodypedia

 KPNA4 antibodies

PROTEIN BROWSER
KPNA4-001
KPNA4-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KPNA4-001
ENSP00000334373
ENST00000334256
O00629 [Direct mapping]
Importin subunit alpha-3
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Transporters
   Transporter channels and pores
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0008139 [nuclear localization sequence binding]
GO:0008565 [protein transporter activity]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0042542 [response to hydrogen peroxide]
GO:0070062 [extracellular exosome]
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 521 aa
57.9 kDa 		No 0
KPNA4-003
ENSP00000417172
ENST00000483437
H7C4F6 [Direct mapping]
Importin subunit alpha-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
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 170 aa
18.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.