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TRDN

GENERAL INFORMATION

Gene name

 TRDN

Gene description

 Triadin

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enhanced (MCF7)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in skeletal muscle and epidermal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA038226 , HPA058226
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038226
HPA058226

GENE INFORMATION

Gene name

 TRDN

Synonyms

Description

 Triadin (HGNC Symbol)

Entrez gene summary

 This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]

Chromosome

 6

Cytoband

 q22.31

Chromosome location (bp)

 123216339 - 123637093

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186439 (version 83.38)

Entrez gene

 10345

UniProt

 Q13061 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13061

Antibodypedia

 TRDN antibodies

PROTEIN BROWSER
TRDN-001
TRDN-002
TRDN-003
TRDN-004
TRDN-005
TRDN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRDN-001
ENSP00000333984
ENST00000334268
Q13061 [Direct mapping]
Triadin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030314 [junctional membrane complex]
GO:0030674 [protein binding, bridging]
GO:0031122 [cytoplasmic microtubule organization]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0034220 [ion transmembrane transport]
GO:0044325 [ion channel binding]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0055085 [transmembrane transport]
GO:0060047 [heart contraction]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0090158 [endoplasmic reticulum membrane organization]
GO:1901846 [positive regulation of cell communication by electrical coupling involved in cardiac conduction]
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 729 aa
81.6 kDa 		No 1
TRDN-002
ENSP00000437684
ENST00000542443
Q13061 [Direct mapping]
Triadin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030314 [junctional membrane complex]
GO:0030674 [protein binding, bridging]
GO:0031122 [cytoplasmic microtubule organization]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0034220 [ion transmembrane transport]
GO:0044325 [ion channel binding]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0055085 [transmembrane transport]
GO:0060047 [heart contraction]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0090158 [endoplasmic reticulum membrane organization]
GO:1901846 [positive regulation of cell communication by electrical coupling involved in cardiac conduction]
Show all
 167 aa
18.5 kDa 		No 1
TRDN-003
ENSP00000406768
ENST00000422596
H0Y6P0 [Direct mapping]
Triadin
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Predicted intracellular proteins
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 44 aa
5.1 kDa 		No 0
TRDN-004
ENSP00000354307
ENST00000361029
H7BY47 [Direct mapping]
Triadin
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Predicted intracellular proteins
Show all
GO:0005102 [receptor binding]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
Show all
 151 aa
17.2 kDa 		No 0
TRDN-005
ENSP00000486095
ENST00000628709
Q13061 [Direct mapping]
Triadin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030314 [junctional membrane complex]
GO:0030674 [protein binding, bridging]
GO:0031122 [cytoplasmic microtubule organization]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0034220 [ion transmembrane transport]
GO:0044325 [ion channel binding]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0055085 [transmembrane transport]
GO:0060047 [heart contraction]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0090158 [endoplasmic reticulum membrane organization]
GO:1901846 [positive regulation of cell communication by electrical coupling involved in cardiac conduction]
Show all
 297 aa
33.2 kDa 		No 1
TRDN-201
ENSP00000439281
ENST00000546248
H9ME53 [Direct mapping]
Cardiac triadin Trisk 32 isoform; Triadin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
Show all
 286 aa
32.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.