Expression of AKAP14 in cancer - Summary

GENERAL INFORMATION
Gene name	AKAP14
Gene description	A kinase (PRKA) anchor protein 14
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membranous expression in ciliated cells in fallopian tube, testis and respiratory epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA060999
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA060999

GENE INFORMATION
Gene name	AKAP14 (HGNC Symbol)
Synonyms	AKAP28
Description	A kinase (PRKA) anchor protein 14 (HGNC Symbol)
Entrez gene summary	The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q24
Chromosome location (bp)	119895837 - 119920716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186471 (version 83.38)
Entrez gene	158798
UniProt	Q86UN6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UN6
Antibodypedia	AKAP14 antibodies

PROTEIN BROWSER

AKAP14-001	AKAP14-002	AKAP14-004	AKAP14-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKAP14-001 ENSP00000334680 ENST00000334356	Q86UN6 [Direct mapping] A-kinase anchor protein 14 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	137 aa 15.9 kDa	No	0
AKAP14-002 ENSP00000360476 ENST00000371422	Q86UN6 [Direct mapping] A-kinase anchor protein 14 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	89 aa 10.2 kDa	No	0
AKAP14-004 ENSP00000360485 ENST00000371431	Q86UN6 [Direct mapping] A-kinase anchor protein 14 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0007283 [spermatogenesis] GO:0035686 [sperm fibrous sheath] GO:0051018 [protein kinase A binding] Show all	197 aa 22.8 kDa	No	0
AKAP14-201 ENSP00000360479 ENST00000371425	Q86UN6 [Direct mapping] A-kinase anchor protein 14 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	137 aa 15.9 kDa	No	0