Expression of CLCNKA in cancer - Summary - The Human Protein Atlas

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CLCNKA

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLCNKA
Gene description	Chloride channel, voltage-sensitive Ka
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (renal cancer, thyroid cancer)
HPA (cell line):	Group enriched (RPMI-8226, SK-BR-3, U-266/70)
HPA (normal tissue):	Group enriched (kidney, parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in kidney, salivary and thyroid glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA057717
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (renal cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057717

GENE INFORMATION
Gene name	CLCNKA (HGNC Symbol)
Synonyms	hClC-Ka
Description	Chloride channel, voltage-sensitive Ka (HGNC Symbol)
Entrez gene summary	This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	16018875 - 16034050
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186510 (version 83.38)
Entrez gene	1187
UniProt	P51800 (UniProt - Evidence at protein level)
neXtProt	NX_P51800
Antibodypedia	CLCNKA antibodies

PROTEIN BROWSER

CLCNKA-001	CLCNKA-002	CLCNKA-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLCNKA-001 ENSP00000332771 ENST00000331433	P51800 [Direct mapping] Chloride channel protein ClC-Ka Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0007588 [excretion] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	687 aa 75.3 kDa	No	>9
CLCNKA-002 ENSP00000364844 ENST00000375692	P51800 [Direct mapping] Chloride channel protein ClC-Ka Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0007588 [excretion] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	686 aa 75.2 kDa	No	>9
CLCNKA-007 ENSP00000414445 ENST00000439316	P51800 [Direct mapping] Chloride channel protein ClC-Ka Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0007588 [excretion] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	644 aa 70.5 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.