Expression of GPATCH8 in cancer - Summary - The Human Protein Atlas

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GPATCH8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPATCH8
Gene description	G patch domain containing 8
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA044380
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044380

GENE INFORMATION
Gene name	GPATCH8 (HGNC Symbol)
Synonyms	GPATC8, KIAA0553
Description	G patch domain containing 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	44395284 - 44503430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186566 (version 83.38)
Entrez gene	23131
UniProt	Q9UKJ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKJ3
Antibodypedia	GPATCH8 antibodies

PROTEIN BROWSER

GPATCH8-001	GPATCH8-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPATCH8-001 ENSP00000467556 ENST00000591680	Q9UKJ3 [Direct mapping] G patch domain-containing protein 8 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	1502 aa 164.2 kDa	No	0
GPATCH8-010 ENSP00000465781 ENST00000585614	K7EKU0 [Direct mapping] G patch domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	221 aa 25.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.