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UBE2H

GENERAL INFORMATION

Gene name

 UBE2H

Gene description

 Ubiquitin-conjugating enzyme E2H

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA003302
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003302

GENE INFORMATION

Gene name

 UBE2H (HGNC Symbol)

Synonyms

 GID3, UBC8, UBCH

Description

 Ubiquitin-conjugating enzyme E2H (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

Chromosome

 7

Cytoband

 q32.2

Chromosome location (bp)

 129830732 - 129952949

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186591 (version 83.38)

Entrez gene

 7328

UniProt

 P62256 (UniProt - Evidence at protein level)

neXtProt

 NX_P62256

Antibodypedia

 UBE2H antibodies

PROTEIN BROWSER
UBE2H-001
UBE2H-003
UBE2H-004
UBE2H-006
UBE2H-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2H-001
ENSP00000347836
ENST00000355621
P62256 [Direct mapping]
Ubiquitin-conjugating enzyme E2 H
A4D1L5 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast); Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast), isoform CRA_b; Ubiquitin-conjugating enzyme E2H isoform 1; Ubiquitin-conjugating enzyme E2H isoform A
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
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 183 aa
20.7 kDa 		No 0
UBE2H-003
ENSP00000419750
ENST00000490974
C9JZG9 [Direct mapping]
Ubiquitin-conjugating enzyme E2 H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
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 103 aa
11.5 kDa 		No 0
UBE2H-004
ENSP00000419689
ENST00000472396
C9JZY6 [Direct mapping]
Ubiquitin-conjugating enzyme E2 H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
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 123 aa
13.8 kDa 		No 0
UBE2H-006
ENSP00000419097
ENST00000473814
P62256 [Direct mapping]
Ubiquitin-conjugating enzyme E2 H
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
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 152 aa
17.2 kDa 		No 0
UBE2H-009
ENSP00000417681
ENST00000496698
C9J8Q9 [Direct mapping]
Ubiquitin-conjugating enzyme E2 H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 149 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.