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ARAP1

GENERAL INFORMATION

Gene name

 ARAP1

Gene description

 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB020703
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), thyroid cancer (favourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001
Thyroid cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB020703

GENE INFORMATION

Gene name

 ARAP1 (HGNC Symbol)

Synonyms

 CENTD2

Description

 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 72685069 - 72793599

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186635 (version 83.38)

Entrez gene

 116985

UniProt

 Q96P48 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96P48

Antibodypedia

 ARAP1 antibodies

PROTEIN BROWSER
«
ARAP1-001
ARAP1-002
ARAP1-003
ARAP1-005
ARAP1-006
ARAP1-007
ARAP1-010
ARAP1-011
ARAP1-014
ARAP1-019
ARAP1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARAP1-001
ENSP00000377233
ENST00000393609
Q96P48 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001921 [positive regulation of receptor recycling]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0030037 [actin filament reorganization involved in cell cycle]
GO:0031410 [cytoplasmic vesicle]
GO:0031702 [type 1 angiotensin receptor binding]
GO:0032580 [Golgi cisterna membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051270 [regulation of cellular component movement]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051497 [negative regulation of stress fiber assembly]
Show all
 1450 aa
162.2 kDa 		No 0
ARAP1-002
ENSP00000352332
ENST00000359373
Q96P48 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0030037 [actin filament reorganization involved in cell cycle]
GO:0032580 [Golgi cisterna membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051270 [regulation of cellular component movement]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051497 [negative regulation of stress fiber assembly]
Show all
 1439 aa
161 kDa 		No 0
ARAP1-003
ENSP00000335506
ENST00000334211
Q96P48 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0030037 [actin filament reorganization involved in cell cycle]
GO:0032580 [Golgi cisterna membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051270 [regulation of cellular component movement]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051497 [negative regulation of stress fiber assembly]
Show all
 1205 aa
135.8 kDa 		No 0
ARAP1-005
ENSP00000392264
ENST00000426523
E7EU13 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005794 [Golgi apparatus]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1194 aa
134.6 kDa 		No 0
ARAP1-006
ENSP00000403127
ENST00000429686
Q96P48 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0030037 [actin filament reorganization involved in cell cycle]
GO:0032580 [Golgi cisterna membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051270 [regulation of cellular component movement]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051497 [negative regulation of stress fiber assembly]
Show all
 1133 aa
127.7 kDa 		No 0
ARAP1-007
ENSP00000377230
ENST00000393605
Q96P48 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0030037 [actin filament reorganization involved in cell cycle]
GO:0032580 [Golgi cisterna membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051270 [regulation of cellular component movement]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051497 [negative regulation of stress fiber assembly]
Show all
 1210 aa
136.3 kDa 		No 0
ARAP1-010
ENSP00000399118
ENST00000452383
F5GWN4 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
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 254 aa
28.8 kDa 		No 0
ARAP1-011
ENSP00000411452
ENST00000427971
F8WBT0 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0007165 [signal transduction]
Show all
 307 aa
34.9 kDa 		No 0
ARAP1-014
ENSP00000441741
ENST00000542596
F5GWQ2 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
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 233 aa
27.1 kDa 		No 0
ARAP1-019
ENSP00000442746
ENST00000536885
H0YGD1 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 178 aa
19.4 kDa 		No 0
ARAP1-201
ENSP00000390461
ENST00000455638
A0A0A0MSJ2 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 679 aa
77.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.