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PDE2A

GENERAL INFORMATION

Gene name

 PDE2A

Gene description

 Phosphodiesterase 2A, cGMP-stimulated

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HeLa)
HPA (normal tissue):Tissue enhanced (cerebral cortex, spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Abundant expression in cerebral cortex and in vessels of spleen.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA031192 , CAB009752
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA031192
CAB009752

GENE INFORMATION

Gene name

 PDE2A

Synonyms

Description

 Phosphodiesterase 2A, cGMP-stimulated (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 72576141 - 72674591

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186642 (version 83.38)

Entrez gene

 5138

UniProt

 O00408 (UniProt - Evidence at protein level)

neXtProt

 NX_O00408

Antibodypedia

 PDE2A antibodies

PROTEIN BROWSER
«
PDE2A-001
PDE2A-003
PDE2A-004
PDE2A-005
PDE2A-008
PDE2A-009
PDE2A-010
PDE2A-012
PDE2A-016
PDE2A-017
PDE2A-018
PDE2A-024
PDE2A-025
PDE2A-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE2A-001
ENSP00000334910
ENST00000334456
O00408 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004112 [cyclic-nucleotide phosphodiesterase activity]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006198 [cAMP catabolic process]
GO:0006626 [protein targeting to mitochondrion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0019933 [cAMP-mediated signaling]
GO:0019934 [cGMP-mediated signaling]
GO:0030224 [monocyte differentiation]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0030911 [TPR domain binding]
GO:0033159 [negative regulation of protein import into nucleus, translocation]
GO:0035690 [cellular response to drug]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0043116 [negative regulation of vascular permeability]
GO:0043117 [positive regulation of vascular permeability]
GO:0045121 [membrane raft]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050729 [positive regulation of inflammatory response]
GO:0061028 [establishment of endothelial barrier]
GO:0070588 [calcium ion transmembrane transport]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071321 [cellular response to cGMP]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
Show all
 941 aa
105.7 kDa 		No 0
PDE2A-003
ENSP00000365633
ENST00000376450
O00408 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004112 [cyclic-nucleotide phosphodiesterase activity]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006198 [cAMP catabolic process]
GO:0006626 [protein targeting to mitochondrion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0019933 [cAMP-mediated signaling]
GO:0019934 [cGMP-mediated signaling]
GO:0030224 [monocyte differentiation]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0030911 [TPR domain binding]
GO:0033159 [negative regulation of protein import into nucleus, translocation]
GO:0035690 [cellular response to drug]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0043116 [negative regulation of vascular permeability]
GO:0043117 [positive regulation of vascular permeability]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050729 [positive regulation of inflammatory response]
GO:0061028 [establishment of endothelial barrier]
GO:0070588 [calcium ion transmembrane transport]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071321 [cellular response to cGMP]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
Show all
 685 aa
78.2 kDa 		Yes 0
PDE2A-004
ENSP00000388997
ENST00000420501
C9JPD5 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
Show all
 198 aa
23.2 kDa 		No 0
PDE2A-005
ENSP00000392457
ENST00000441209
H7C009 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0046872 [metal ion binding]
Show all
 327 aa
37.4 kDa 		No 0
PDE2A-008
ENSP00000439077
ENST00000475807
H0YFL1 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 336 aa
37.2 kDa 		No 0
PDE2A-009
ENSP00000443232
ENST00000542969
F5H5P8 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 87 aa
9.5 kDa 		No 0
PDE2A-010
ENSP00000410310
ENST00000418754
E9PEF1 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0046872 [metal ion binding]
Show all
 826 aa
93.6 kDa 		No 0
PDE2A-012
ENSP00000446399
ENST00000540345
O00408 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004112 [cyclic-nucleotide phosphodiesterase activity]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006198 [cAMP catabolic process]
GO:0006626 [protein targeting to mitochondrion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0019933 [cAMP-mediated signaling]
GO:0019934 [cGMP-mediated signaling]
GO:0030224 [monocyte differentiation]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0030911 [TPR domain binding]
GO:0033159 [negative regulation of protein import into nucleus, translocation]
GO:0035690 [cellular response to drug]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0043116 [negative regulation of vascular permeability]
GO:0043117 [positive regulation of vascular permeability]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050729 [positive regulation of inflammatory response]
GO:0061028 [establishment of endothelial barrier]
GO:0070588 [calcium ion transmembrane transport]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071321 [cellular response to cGMP]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
Show all
 932 aa
105 kDa 		No 0
PDE2A-016
ENSP00000445750
ENST00000536458
F5H1D7 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 92 aa
9.6 kDa 		No 0
PDE2A-017
ENSP00000439683
ENST00000538749
F5H130 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
15.3 kDa 		No 0
PDE2A-018
ENSP00000442256
ENST00000544570
O00408 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004112 [cyclic-nucleotide phosphodiesterase activity]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006198 [cAMP catabolic process]
GO:0006626 [protein targeting to mitochondrion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0019933 [cAMP-mediated signaling]
GO:0019934 [cGMP-mediated signaling]
GO:0030224 [monocyte differentiation]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0030911 [TPR domain binding]
GO:0033159 [negative regulation of protein import into nucleus, translocation]
GO:0035690 [cellular response to drug]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0043116 [negative regulation of vascular permeability]
GO:0043117 [positive regulation of vascular permeability]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050729 [positive regulation of inflammatory response]
GO:0061028 [establishment of endothelial barrier]
GO:0070588 [calcium ion transmembrane transport]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071321 [cellular response to cGMP]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
Show all
 934 aa
105.1 kDa 		Yes 0
PDE2A-024
ENSP00000441322
ENST00000538299
H0YG13 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 172 aa
18.8 kDa 		No 0
PDE2A-025
ENSP00000440834
ENST00000542223
F5GXX2 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0046872 [metal ion binding]
Show all
 178 aa
20.5 kDa 		No 0
PDE2A-201
ENSP00000411657
ENST00000444035
O00408 [Direct mapping]
cGMP-dependent 3',5'-cyclic phosphodiesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004112 [cyclic-nucleotide phosphodiesterase activity]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006198 [cAMP catabolic process]
GO:0006626 [protein targeting to mitochondrion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0019933 [cAMP-mediated signaling]
GO:0019934 [cGMP-mediated signaling]
GO:0030224 [monocyte differentiation]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0030911 [TPR domain binding]
GO:0033159 [negative regulation of protein import into nucleus, translocation]
GO:0035690 [cellular response to drug]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0043116 [negative regulation of vascular permeability]
GO:0043117 [positive regulation of vascular permeability]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050729 [positive regulation of inflammatory response]
GO:0061028 [establishment of endothelial barrier]
GO:0070588 [calcium ion transmembrane transport]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071321 [cellular response to cGMP]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
Show all
 920 aa
103.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.