Expression of PRG2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PRG2

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRG2
Gene description	Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (HL-60, HMC-1, NB-4)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in placenta and bone marrow.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA038515
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038515

GENE INFORMATION
Gene name	PRG2 (HGNC Symbol)
Synonyms	BMPG, MBP
Description	Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	57386794 - 57390657
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186652 (version 83.38)
Entrez gene	5553
UniProt	P13727 (UniProt - Evidence at protein level)
neXtProt	NX_P13727
Antibodypedia	PRG2 antibodies

PROTEIN BROWSER

PRG2-001	PRG2-002	PRG2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRG2-001 ENSP00000312134 ENST00000311862	P13727 [Direct mapping] Bone marrow proteoglycan Eosinophil granule major basic protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002215 [defense response to nematode] GO:0005576 [extracellular region] GO:0006955 [immune response] GO:0008201 [heparin binding] GO:0030133 [transport vesicle] GO:0030246 [carbohydrate binding] GO:0032693 [negative regulation of interleukin-10 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0042035 [regulation of cytokine biosynthetic process] GO:0042742 [defense response to bacterium] GO:0070062 [extracellular exosome] Show all	222 aa 25.2 kDa	Yes	0
PRG2-002 ENSP00000433016 ENST00000525955	P13727 [Direct mapping] Bone marrow proteoglycan Eosinophil granule major basic protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006955 [immune response] GO:0008201 [heparin binding] GO:0030133 [transport vesicle] GO:0030246 [carbohydrate binding] GO:0042035 [regulation of cytokine biosynthetic process] GO:0042742 [defense response to bacterium] GO:0070062 [extracellular exosome] Show all	222 aa 25.2 kDa	Yes	0
PRG2-003 ENSP00000433231 ENST00000533605	P13727 [Direct mapping] Bone marrow proteoglycan Eosinophil granule major basic protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006955 [immune response] GO:0008201 [heparin binding] GO:0030133 [transport vesicle] GO:0030246 [carbohydrate binding] GO:0042035 [regulation of cytokine biosynthetic process] GO:0042742 [defense response to bacterium] GO:0070062 [extracellular exosome] Show all	211 aa 23.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.