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BCR

GENERAL INFORMATION

Gene name

 BCR

Gene description

 Breakpoint cluster region

Protein class

 Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA038337 , CAB010421 , CAB018545
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038337
CAB010421
CAB018545

GENE INFORMATION

Gene name

 BCR (HGNC Symbol)

Synonyms

 ALL, BCR1, CML, D22S11, D22S662, PHL

Description

 Breakpoint cluster region (HGNC Symbol)

Entrez gene summary

 A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q11.23

Chromosome location (bp)

 23179704 - 23318037

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186716 (version 83.38)

Entrez gene

 613

UniProt

 P11274 (UniProt - Evidence at protein level)

neXtProt

 NX_P11274

Antibodypedia

 BCR antibodies

PROTEIN BROWSER
BCR-001
BCR-002
BCR-006
BCR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCR-001
ENSP00000303507
ENST00000305877
P11274 [Direct mapping]
Breakpoint cluster region protein
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002692 [negative regulation of cellular extravasation]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0030336 [negative regulation of cell migration]
GO:0032496 [response to lipopolysaccharide]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042472 [inner ear morphogenesis]
GO:0043114 [regulation of vascular permeability]
GO:0043234 [protein complex]
GO:0043314 [negative regulation of neutrophil degranulation]
GO:0043547 [positive regulation of GTPase activity]
GO:0045211 [postsynaptic membrane]
GO:0046777 [protein autophosphorylation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051726 [regulation of cell cycle]
GO:0060313 [negative regulation of blood vessel remodeling]
GO:0070062 [extracellular exosome]
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 1271 aa
142.8 kDa 		No 0
BCR-002
ENSP00000352535
ENST00000359540
P11274 [Direct mapping]
Breakpoint cluster region protein
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030054 [cell junction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045211 [postsynaptic membrane]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
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 1227 aa
137.7 kDa 		No 0
BCR-006
ENSP00000396531
ENST00000427791
H0Y554 [Direct mapping]
Breakpoint cluster region protein
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 257 aa
29.6 kDa 		No 0
BCR-201
ENSP00000381524
ENST00000398512
A9UF01 [Direct mapping]
BCR/ABL fusion protein isoform X8; Breakpoint cluster region protein
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005096 [GTPase activator activity]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 465 aa
51.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.