Expression of SPIN2B in cancer - Summary - The Human Protein Atlas

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SPIN2B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPIN2B
Gene description	Spindlin family, member 2B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA000162
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000162

GENE INFORMATION
Gene name	SPIN2B (HGNC Symbol)
Synonyms	SPIN-2, TDRD26
Description	Spindlin family, member 2B (HGNC Symbol)
Entrez gene summary
Chromosome	X
Cytoband	p11.21
Chromosome location (bp)	57118551 - 57121547
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000186787 (version 83.38)
Entrez gene	474343
UniProt	Q9BPZ2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BPZ2
Antibodypedia	SPIN2B antibodies

PROTEIN BROWSER

SPIN2B-001	SPIN2B-002	SPIN2B-003	SPIN2B-005	SPIN2B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPIN2B-001 ENSP00000275988 ENST00000275988	Q9BPZ2 [Direct mapping] Spindlin-2B A0A024R9Y9 [Target identity:100%; Query identity:100%] Spindlin-like protein 2, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0007276 [gamete generation] Show all	258 aa 29.2 kDa	No	0
SPIN2B-002 ENSP00000364047 ENST00000374912	Q9BPZ2 [Direct mapping] Spindlin-2B A0A024R9Y9 [Target identity:100%; Query identity:100%] Spindlin-like protein 2, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0007276 [gamete generation] Show all	258 aa 29.2 kDa	No	0
SPIN2B-003 ENSP00000404314 ENST00000434397	Q5JZB8 [Direct mapping] Spindlin-2B Show all	Predicted intracellular proteins Show all	GO:0007276 [gamete generation] Show all	247 aa 27.8 kDa	No	0
SPIN2B-005 ENSP00000364045 ENST00000374910	Q5JZB7 [Direct mapping] Spindlin-2B; Spindlin-like protein 2, isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0007276 [gamete generation] Show all	157 aa 17.6 kDa	No	0
SPIN2B-201 ENSP00000335008 ENST00000333933	Q9BPZ2 [Direct mapping] Spindlin-2B A0A024R9Y9 [Target identity:100%; Query identity:100%] Spindlin-like protein 2, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0007276 [gamete generation] Show all	258 aa 29.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.